The personalized approaches in the treatment of head and neck cancer (PATH) study is a longitudinal study of head and neck cancer patients in BC currently recruiting patients. The aims of the project are to determine the molecular correlates of relapse in head and neck cancer and to compare virus-positive (HPV and EBV) and virus-negative cases in terms of genomic and epigenomic features. To achieve this, tumour samples are undergoing short- and long-read whole-genome sequencing (WGS), as well as RNA-sequencing. In particular, long-read WGS will allow us to probe virus-associated structural variation (SV) and methylation and to compare these features to other forms of SV and methylation in virus-negative cases.