Our research labs are located at the BC Cancer Research Centre, the Echelon Innovation Centre, the University of British Columbia and Simon Fraser University. Together, our thirteen faculty members broadly apply their expertise in genomics, bioinformatics and proteomics to advance knowledge of cancer and other diseases.
Dr. Marra's research is focused on the development and application of next generation sequencing for the characterization of cancer genomes, transcriptomes and epigenomes, and the functional interplay between cancer genomes and epigenomes.
Dr. Jones' team uses bioinformatics to investigate the landscape of mutations present in cancer genomes and the early genomic events that give rise to and promote the progression of cancer.
Dr. Brooks-Wilson's research is focused on the genetic basis of cancer susceptibility as well as on healthy aging, focusing on individuals 85 and older who have never been diagnosed with cancer, cardiovascular disease, major pulmonary disease, diabetes or dementia.
Dr. Holt's laboratory uses deep sequencing methods and computational tools to explore the role of T cells in cancer, to identify the spectrum of somatic mutations in various cancers and to study the links between cancer and infectious agents.
Gregg Morin Lab
Dr. Morin's research focuses on understanding the function of somatically mutated cancer genes, and on developing methods for ultra high proteome coverage and quantification of fresh-frozen paraffin-embedded tumour sections.
Dr. Sadar’s research is focused on the development of therapeutics for prostate cancer, with a particular focus on the N-terminus of the androgen receptor.
Dr. Gorski's research is focused on treatment resistance in HER2+ breast cancer, new strategies to target pancreatic ductal adenocarcinoma, and the role of autophagy in Drosophila development and its interplay with cellular stress response pathways.
Dr. Karsan's research is focused on understanding the molecular basis of myeloid malignancies and determining the role of the endothelium in the development of the hematopoietic system.
Dr. Birol's lab aims to develop novel algorithms, data structures and genome analysis and visualization software, including complete and scalable solutions for de novo genome assembly.
Dr. Hirst's research is focused on understanding the role of epigenetics in cancer and investigating the therapeutic potential of interventions directed at epigenetic processes.
Ryan Morin Lab
Dr. Morin's research is focused on applying the latest molecular and computational methods in cancer genomics to develop and implement highly sensitive molecular assays for monitoring circulating tumour DNA, and functionally validating genomic findings.
Dr. Tai's research is focused on understanding the mechanisms of chemotherapy resistance, metastasis and tumour progression in gastrointestinal cancers using genomics and proteomics approaches.
Dr. Wyatt’s research is focused on metastatic genitourinary cancers, including prostate and bladder cancer.
Dr. Laura Evgin’s research is focused on chimeric antigen receptor (CAR) modified T cells and their use in conjunction with oncolytic viruses (OVs).
Dr. Adi Steif's research is focused on developing and applying statistical machine learning methods for high-throughput biology, with a particular interest in single cell genomics and tumour evolution.