We provide high throughput, targeted and whole genome sequencing in a CAP and DAP certified laboratory. Our combination of scientific, technical, informatic and clinical expertise means  you can be confident that our data and diagnostics are of the highest quality.

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The GSC is CAP and DAP certified to provide whole genome sequencing up to the production of BAM files.

The Oncopanel detects mutations with known occurrence in the development of solid tumours within the following 48 genes:

AKT1, ALK, APC, ATM, BMPR1A, BRAF, BRCA1, BRCA2, CDH1, CDK4, CDKN2A, CHEK2, CIC, EGFR, ERBB2 (HER2), ERBB3 (HER3), FUBP1, GNA11, GNAQ, HRAS, IDH1, IDH2, KIT, KRAS, MAP2K1 (MEK1), MET (HGFR), MLH1, MSH2, MSH6, MUTYH, NF1, NRAS, PALB2, PDGFRA, PIK3CA, PMS2, POLD1, POLE, PTEN, RET, ROS1, SDHA, SDHB, SDHC, SDHD, SMAD4, STK11, TP53.
 

If ordering within British Columbia, please refer to the Cancer Genetics Lab website for details including turn around times.

If ordering from outside of British Columbia, please contact us for details and requisition forms.

The development of our next-generation sequencing assay is described in Bosdet et al. 2013.

The Myeloid Panel detects small mutations associated with acute myeloid leukemia, myeloproliferative neoplasms and myelodysplastic syndromes, in the following 51 genes:

ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DDX41, DKC1, DNMT3A, ETV6, EZH2, FLT3, GATA2, HRAS, IDH1, IDH2, JAK2, KDM6A, KIT, KRAS, MPL, NF1, NPM1, NRAS, PHF6, PIGA, PRPF40B, PTEN, PTPN11, RAD21, RTEL1, RUNX1, SETD2, SF1, SF3A1, SF3B1, SH2B3, SMC1A, SMC3, SOCS3, SRSF2, STAG2, TERC, TERT, TET2, TP53, U2AF1, U2AF2, WT1, ZRSR2.

Copy number variants are detected in the following 2 genes:

FLT3, KMT2A (MLL)

If ordering within British Columbia, please refer to the Cancer Genetics Lab website for details including turn around times.

If ordering from outside of British Columbia, please contact us for details and requisition forms.

The development of our next-generation sequencing assay is described in Bosdet et al. 2013.

The Hereditary Cancer Panel is available to people across Canada and includes testing for small mutations in the following 82 genes:

AIP, ALK, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CASR, CDC73, CDH1, CDK4, CDKN1B, CDKN1C, CDKN2A, CEBPA, CHEK2, CTNNA1, DICER1, DIS3L2, EGFR, FH, FLCN, GATA2, GPC3, HOXB13, HRAS, KIT, MAX, MEN1, MET, MITF, MLH1, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, PALB2, PDGFRA, PHOX2B, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RB1, RECQL4, RET, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TERC, TERT, TMEM127, TP53, TSC1, TSC2, VHL, WRN, WT1.

A list of ACMG 1, 2 and 3 variants with clinical interpretation will be reported.

Variants in exons 12 and 15 of PMS2 are not reported.

Referrals for this assay must be requested through BC Cancer's Hereditary Cancer Program.

If ordering from outside of British Columbia, please contact us for details and requisition forms.

The Prostate Cancer circulating tumour DNA (ctDNA) Panel detects small mutations and copy number variants in the following 3 genes:

ATM, BRCA1, BRCA2.

Germline small mutations affecting these genes are also detected in constitutional blood.

If ordering within British Columbia, please refer to the Cancer Genetics Lab website.

If ordering from outside of British Columbia, please contact us for details and requisition forms.

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