Substantial advancements in healthcare economics can be realized through the development of genomics technologies to detect variations and mutations in DNA and RNA in a manner that allows effective preventative care and/or efficient diagnosis and treatment. One technology that will enable this vision is high throughput DNA and RNA sequencing. This requires proper downstream data analysis and interpretation. To address this challenge, Dr. Birol’s group is building and validating bioinformatics pipelines for clinical use. In collaborative projects, they are deploying these pipelines for cancer care and diagnosis of rare genetic diseases.