The length of a coding transcript’s tail end (3’ UTR) can affect its stability, transport and translation, with important regulatory consequences. Alternative cleavage of transcripts at the 3’ UTR (alternative polyadenylation) is a difficult to study phenomenon, often requiring specialized and relatively expensive experimental methods. As a solution to this problem, Dr. Birol’s group is building bioinformatics tools using standard transcriptome sequencing (RNA-seq) datasets to catalogue alternative polyadenylation in large cancer cohorts.
Alternative polyadenylation
Canada’s Michael Smith Genome Sciences Centre respectfully acknowledges that we operate on the traditional, ancestral and unceded territories of the xʷməθkwəy̓əm (Musqueam), Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh), and Skwxwú7mesh (Squamish) nations who have cared and nurtured this land for all time. We give thanks, as uninvited guests, to be able to live and work on these lands.
