About the GSC

Advancing Genomics Technologies for Health and Life Sciences

 

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No. PDF_01553_Postdoctoral Fellow_Jones Lab_2026_06_07

 

Background

The Parent-of-Origin-Aware genomic analysis (POAga) project is part of a major hereditary cancer genomics initiative focused on enhancing population cancer care through mainstream genome sequencing and parent-of-origin detection. The project will generate 6,585 short-read genomes from a diverse patient cohort, 900 long-read phased genomes with parent-of-origin data, 40 diverse POAga carriers to support cascade testing, and 60 parent-child trios for validation. The work includes short-read and long-read whole-genome sequencing, Strand-seq, variant calling, methylation analysis, chromosome-scale phasing, and parent-of-origin assignment to improve hereditary cancer risk assessment and family-based follow-up.

The Sarcoma MetAstasis Research Taskforce (SMART) project aims to identify therapeutic targets relevant to preventing or treating metastasis and relapse in high-risk pediatric sarcomas, including Ewing sarcoma, osteosarcoma, and rhabdomyosarcoma. The project integrates multimodal molecular profiling of relapse and metastatic samples using single nuclei RNA sequencing, spatial proteomics, bulk DNA/RNA/methylation profiling, circulating tumor DNA analysis, extracellular vesicle profiling, and exploratory nanopore- and SERS-based assays for biomarker and assay development.

This Post Doctoral Fellow will provide dedicated computational expertise across both projects by building and operating reproducible analytical pipelines, integrating high-dimensional genomic and multi-omic datasets, supporting quality control and documentation, and helping translate complex molecular data into biologically and clinically meaningful findings. Both POAga and SMART depend on advanced sequencing and data integration workflows, making this position central to successful project delivery.

Responsibilities

• Develop, implement, maintain, and document reproducible bioinformatics workflows for short-read and long-read whole-genome sequencing, methylation analysis, haplotype phasing, and parent-of-origin assignment for the POAga project.
• Support analysis of Strand-seq and long-read sequencing datasets, including alignment, variant calling, annotation, quality control, phasing, and integration with genomic and clinical metadata.
• Build and optimize analysis pipelines for SMART project datasets spanning bulk DNA/RNA/methylation profiling, single nuclei RNA-seq, spatial proteomics, ctDNA, extracellular vesicle profiling, and exploratory nanopore-based liquid biopsy assays.
• Integrate multimodal datasets to identify therapeutic targets, biomarkers of relapse and metastasis, and biologically meaningful patterns across patient samples and model systems.
• Generate analysis reports, figures, quality summaries, and data packages for collaborators, presentations, manuscripts, and project reporting.
• Work closely with investigators, trainees, clinical teams, and laboratory personnel to prioritize analyses, harmonize data standards, and support milestone completion across both projects.
• Contribute to data stewardship, metadata harmonization, workflow reproducibility, and preparation of research outputs consistent with institutional and project data governance requirements.
• These responsibilities reflect the sequencing, phasing, single-cell, spatial proteomics, ctDNA, and assay-development activities described in the POAga and SMART project materials.

Qualifications

• PhD in Bioinformatics, Computational Biology, Genomics, Computer Science, Statistics, or a related discipline; or an equivalent combination of education and experience.
• Expertise in next-generation sequencing data analysis, preferably including Illumina short-read and Oxford Nanopore long-read platforms.
• Experience with one or more of the following: germline or cancer variant calling, structural variant analysis, copy-number analysis, methylation analysis, haplotype phasing, RNA-seq analysis, single-cell analysis, spatial omics, ctDNA analysis, or multi-omic data integration.
• Strong programming skills in Python and/or R, with experience using workflow managers such as Nextflow, Snakemake, or CWL, version control tools such as Git, and high-performance computing environments.
• Demonstrated ability to analyze complex genomic datasets and produce reproducible, well-documented workflows.
• Familiarity with hereditary cancer genomics, cancer biology, translational genomics, liquid biopsy approaches, or pediatric cancer research is strongly preferred.
• Excellent communication and interpersonal skills, with the ability to work effectively in a multidisciplinary team.
• These qualifications are aligned with the technical methods and computational scope described for both projects.

 

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid – onsite 3 days/week

 

Salary Range: 

$70,000 to $75,000 p.a.

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

 

Apply

 

Please submit a detailed cover letter and resume highlighting relevant research experience, interests and goals; and the names and contact details of three references to bcgscjobs@bcgsc.ca , using PDF_01553_Postdoctoral Fellow_Jones Lab_2026_06_07 in the subject line of your email.

 

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

 

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

 

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

 

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

 

About the GSC

Advancing Genomics Technologies for Health and Life Sciences

Canada’s Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No. RPC2_R00026_197705_Collaborative Services_2026_04_17

Summary

Reporting to the Head, Business Development and Collaborative Services and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones.

Duties/Accountabilities

• Establishing budgets for research projects, grants, collaborations and core activities
• Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
• Monitoring budgets and expenditures
• Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives
• Recommending strategies for improving projects management methods and processes
• Liaising with grant/core funding agencies
• Interacting directly with research collaborators or clinical study teams as required
• Performing other related duties as appropriate

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, biotech or software industry.

Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at the Research Project Coordinator level, which is equivalent to that described above.

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the PHSA group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid

Salary Range: 

$76,111 – $109,409 p.a.

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Higher salary offers above the midpoint range require additional review and approval.

Apply:

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. RPC2_R00026_197705_Collaborative Services_2026_04_17 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction of offence unrelated to their employment.

 

Advancing Genomics Technologies for Health and Life Sciences

The Michael Smith Genome Sciences Centre (GSC), a provincial program within the Provincial Health Services Authority (PHSA), is a recognized international leader in genomics, bioinformatics, and genome technology innovation. By developing and deploying cutting-edge sequencing and computational platforms, the GSC supports breakthrough research across cancer, rare and infectious diseases, and the broader life sciences. Our work enables earlier diagnosis, novel therapeutic approaches, and transformative applications of genomics to improve human health and environmental resilience—delivering both social and economic impact through science.

Job Reference No. CB_P01066_HSA194506_SoftDev_2026_01_30

Job Summary

In accordance with the Purpose, Vision, Values and Coast Salish Teachings, and strategic direction of PHSA, safety, including both patient and employee safety, is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist participates in developing, improving and maintaining bioinformatics tools for high-throughput processing pipelines. The Computational Biologist specifies, implements, tests and maintains bioinformatics computer applications and systems, and participates in the code walk-throughs and design and review of bioinformatics software solutions. The Computational Biologist will also assist in the packaging and distribution of developed tools and analysis results to the scientific community, and will contribute to the preparation of scientific publications.

Duties

1. Codes in Python and specifies, implements, tests, and maintains bioinformatics pipelines and applications as assigned.
2. Assists with devising or modifying systems to solve complex problems associated with high throughput pipelines, considering computer equipment capacity and limitations, operating time and form of desired results.
3. Participates in code walk-throughs and reviews of the coded solutions to PEP8 standards.
4. Participates in the design and build of database and software solutions taking performance into consideration.
5. Coordinates production problem resolution for assigned applications, including working with other technical teams.
6. Evaluates third-party software and incorporates new systems into legacy systems.
7. Produces written documentation of algorithms, validations, SOPs, and other processes related to pipeline updates and procedures as required.
8. Presents results of bioinformatics software testing internally and externally.
9. Performs literature searches, testing and validation of new data analysis software related to bioinformatics pipelines.
10. Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Computer Science, Biological Sciences, or equivalent program.
• Two (2) years of recent related experience in a bioinformatic setting or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Demonstrated expertise with Python or other similar high level languages for application in data analysis.
• Demonstrated ability to program and run analysis in a high throughput bioinformatics production environment.
• Functional knowledge of distributed version control systems, such as GIT.
• Functional knowledge of Agile development and ticketing systems.
• Demonstrated ability to work with bioinformatics workflow managers (e.g. Nextflow).
• Excellent verbal and written communication skills.
• Demonstrated ability to work in an Unix environment, including experience with shell scripting and common command-line tools.
• Demonstrated ability to develop software as part of a team.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the PHSA group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Hybrid

Salary Range: 

Grid 9 - $37.89/hour for the 1st year - $47.20/ hour for the 6th year

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and grant fund availability.

Higher salary offers above the midpoint range require additional review and approval.

Apply:

As this is a union position, you will also have to apply either as an internal or external applicant through http://www.phsa.ca/careers using the posting reference 194506.

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. CB_P01066_HSA194506_SoftDev_2026_01_30 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

COVID-19 vaccines protect against infection from severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) that causes COVID-19. 

The COVID-19 vaccine has been added to the list of high-priority immunizations recommended for health-care workers. Health care workers should ensure they are up-to-date on all routine immunizations. 

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.