Developing and deploying genomics technologies in support of cancer and life sciences research.

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying cutting-edge genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science. 

Technology Platform

The GSC is available to support your research. We guide experimental design, facilitate the processing of complex biological samples and provide numerous sequencing and bioinformatic services with the aim of making genomics accessible to the international scientific community. Explore our technology platforms and services, and if you have questions or would like to collaborate please fill out our contact form or speak directly with one of our platform leaders.

The GSC is ISO27001 certified for information security management.

Scientific Research

The 16 faculty members at the GSC have a diverse range of expertise in genomics, bioinformatics, proteomics, epigenomics, immunogenetics, cancer biology, computer science and software development. Together, we apply our knowledge to advance the global understanding of cancer and other diseases with an ultimate aim toward improving human health through disease prevention, the development of novel diagnostic strategies and by uncovering new therapeutic approaches, all the while helping the world to realize the social and economic benefits of genome research.

Clinical Programs

The GSC is unique in that it fosters close collaborations between scientists and clinicians, allowing for an unencumbered focus on direct translational research. Through the Personalized OncoGenomics (POG) program, the GSC deploys whole genome and transcriptome sequencing to inform therapeutic and management strategies for late-stage cancer patients in real time. The GSC is also certified by the College of American Pathologists (CAP) and the Diagnostic Accreditation Program (DAP) to perform clinical genomic panel testing.

Questions?

Please feel free to speak with one of our Platform Leaders directly:

Directors & Platform Leaders

News

Nov 04, 2024

Reflections from our Inaugural GSC Collaborator Forum 2024

Since our founding in 1999, the GSC has sequenced over 6,000,000,000,000,000 bases, sequenced the genomes of more than 350 species, and facilitated ground-breaking discoveries in cancer research. On October 22, 2024, we hosted our inaugural Collaborator Forum, bringing together a vibrant mix of researchers, industry experts, and both old and new colleagues to celebrate decades of collaboration and to foster new scientific partnerships.

Sep 20, 2024

Registration Now Open for Inaugural GSC Collaborator Forum

Registrations are now open for the Inaugural GSC Collaborator Forum on Tuesday, October 22nd!

An exciting line-up of invited speakers will share insights into topics ranging from plant genomes to the latest advances in cancer research. Join us for a day of sharing technical expertise and networking with Vancouver’s vibrant genomic research community!

Register here: https://www.eventbrite.com/e/gsc-collaborator-forum-tickets-1005351151357?aff=oddtdtcreator

Publications

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Nature Genetics, 2020
Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemaçon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomäki, M Rosario Alonso, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Bernd Auber, Paul L Auer, Jacopo Azzollini, Judith Balmaña, Rosa B Barkardottir, Daniel Barrowdale, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Katarzyna Białkowska, Amie M Blanco, Carl Blomqvist, William Blot, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Ake Borg, Kristin Bosse, Hiltrud Brauch, Hermann Brenner, Ignacio Briceno, Ian W Brock, Angela Brooks-Wilson et al.

In search of genetic factors predisposing to familial hairy cell leukemia (HCL): exome-sequencing of four multiplex HCL pedigrees

Leukemia, 2020
Alexander Pemov, Anand Pathak, Samantha J Jones, Ramita Dewan, Jessica Merberg, Sirisha Karra, Jung Kim, Evgeny Arons, Sarangan Ravichandran, Brian T Luke, Shalabh Suman, Meredith Yeager, Martin J S Dyer, Henry T Lynch, Mark H Greene, Neil E Caporaso, Robert J Kreitman, Lynn R Goldin, John J Spinelli, Angela Brooks-Wilson, Mary L McMaster, Douglas R Stewart
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