A genomics approach was undertaken to determine a signature profile of genes that are differentially expressed in chemotherapy resistance in colorectal cancers. Unique signatures were identified that are specific to 5-fluorouracil, irinotecan, etoposide and cisplatin resistance in colorectal cancers, as well as a profile that represents "global" resistance to chemotherapy. The overall goal of this project will be to develop a "Genomics Map" of Cancer Therapy Resistance. In order to achieve this objective, Dr. Tai's laboratory is systematically delineating the importance of these differentially expressed genes in chemo- and radiation therapy resistance in gastrointestinal cancers.
Mechanisms of Chemotherapy Resistance in Gastrointestinal Cancers
Canada’s Michael Smith Genome Sciences Centre respectfully acknowledges that we operate on the traditional, ancestral and unceded territories of the xʷməθkwəy̓əm (Musqueam), Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh), and Skwxwú7mesh (Squamish) nations who have cared and nurtured this land for all time. We give thanks, as uninvited guests, to be able to live and work on these lands.
