Order	SeqName	SeqType	IsAE	NBL01_MYCN	NBL05_MYCN	NBL09_MYCN	NBL10_MYCN	NBL02	NBL03	NBL04	NBL06	NBL07	NBL08	NBL11_Rel2	NBL11_Rem1	NBL11_Rel1	NBL12_Rel_Left	NBL12_Rel_Right	NBL13_Rel_Left	NBL13_Rel_Right	NBL14_MYCN_Met	NBL14_MYCN_Pri	NBL15_MYCN_Rel1	SKP01	SKP02	SKP03
1	RP11-421L21.2	Gene	0	55.76	46.51	20.10	47.13	44.64	38.94	23.50	16.89	10.10	24.92	9.54	41.62	60.65	41.20	39.70	28.21	24.18	17.19	28.54	25.42	14.04	16.89	12.00
2	421013	Transcript	0	7.41	9.01	0.97	3.86	7.73	6.17	3.95	1.67	1.38	3.03	4.14	7.81	13.70	11.09	5.83	5.60	3.46	5.84	6.05	7.40	2.62	3.70	4.30
3	453011	Transcript	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
4	446527	Transcript	0	2.96	0.00	1.83	1.40	4.33	2.78	0.00	2.09	1.79	2.66	4.84	5.40	6.66	6.77	8.90	0.00	0.00	0.00	8.09	0.00	5.81	2.94	0.00
5	416329	Transcript	0	0.00	0.00	0.00	0.19	0.00	0.00	0.05	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.41	0.46	0.00	0.00	0.37	0.00	0.00	0.00
6	454721	Transcript	0	0.00	12.76	6.68	8.32	15.20	31.91	4.02	2.55	1.22	8.92	0.00	51.02	21.26	10.30	0.00	17.60	17.67	4.77	8.47	2.43	2.84	5.14	4.01
7	449473	Transcript	0	4.23	2.03	0.00	2.04	5.35	0.92	1.32	0.00	0.00	2.29	0.00	0.00	0.00	2.44	5.80	0.00	3.30	0.00	3.19	0.00	0.00	0.00	0.00
8	451213	Transcript	0	76.91	80.08	27.53	65.96	54.51	36.14	32.04	17.21	8.47	27.27	6.00	40.84	60.68	23.71	22.88	17.93	14.32	21.49	28.10	20.73	8.47	14.27	10.60
9	ER1a	ExonRegion	0	9.69	5.94	0.57	0.63	0.72	9.80	4.43	0.00	0.71	0.62	0.00	0.00	0.00	0.50	0.00	6.06	0.00	0.00	4.17	4.99	1.19	0.00	7.23
10	ER1b	ExonRegion	1	37.27	15.87	3.14	1.36	7.18	46.25	13.05	0.55	1.54	4.67	1.04	0.00	0.00	14.62	16.98	31.39	0.48	2.03	19.03	17.75	14.46	2.19	19.55
11	E1_Ac	KnownBoundary	0	58.97	14.93	6.18	3.60	18.08	69.68	14.75	3.41	3.88	11.04	4.16	0.00	5.84	36.02	49.45	52.38	8.79	14.96	34.82	23.59	28.17	5.39	15.54
12	ER1c	ExonRegion	0	18.99	13.96	5.78	7.54	12.85	19.02	6.56	10.57	3.50	10.50	6.42	3.81	2.15	22.81	26.30	19.15	14.95	9.24	14.92	12.39	26.54	3.37	11.54
13	E1a_E3a	KnownJunction	0	3.78	8.88	6.45	9.62	4.16	13.63	2.25	11.21	6.11	9.94	11.27	11.10	19.64	20.43	10.26	23.33	8.13	7.83	9.60	37.33	26.63	0.00	7.60
14	E1a_E4b	KnownJunction	0	2.96	0.00	1.83	1.40	4.33	2.78	0.00	2.09	1.79	2.66	4.84	5.40	6.66	6.77	8.90	0.00	0.00	0.00	8.09	0.00	5.81	2.94	0.00
15	E1a_E5a	NovelJunction	0	0.00	0.00	0.00	0.00	0.00	8.01	0.00	5.09	1.74	4.19	2.05	0.00	0.00	2.24	14.34	0.00	9.07	0.00	0.00	0.00	5.19	0.00	0.00
16	E1a_E8b	NovelJunction	0	0.00	3.22	0.00	0.00	0.00	0.00	0.00	0.00	0.00	5.00	0.00	0.00	0.00	2.47	4.70	0.00	0.00	2.03	0.00	0.00	12.54	0.00	0.00
17	E1a_E10a	NovelJunction	0	0.00	2.50	2.84	1.56	0.00	2.61	1.63	0.00	3.36	5.37	6.79	0.00	0.00	2.12	24.97	0.00	8.23	8.75	0.00	5.31	0.00	5.45	7.94
18	I1	Intron	0	5.62	2.60	1.40	3.97	4.19	1.28	5.46	2.20	0.99	2.16	1.56	16.92	18.89	6.50	4.32	6.04	7.03	1.33	1.80	5.16	1.00	0.52	0.98
19	I1_SR1	SilentIntronRegion	0	6.66	2.66	1.48	4.41	4.52	1.61	6.35	2.18	0.97	2.04	2.28	21.50	23.16	8.35	5.43	7.69	8.79	1.63	2.33	6.15	1.17	0.69	1.22
20	I1_AR5	ActiveIntronRegion	0	6.35	0.00	2.45	2.50	9.22	0.00	3.97	3.46	1.99	5.93	0.00	8.66	16.94	7.49	8.70	9.91	7.15	1.13	6.37	1.65	1.47	2.08	2.94
21	ER2a	ExonRegion	0	0.00	0.00	0.00	0.19	0.00	0.00	0.05	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.41	0.46	0.00	0.00	0.37	0.00	0.00	0.00
22	I2	Intron	0	1.88	1.24	0.68	1.58	2.66	1.25	3.72	1.17	0.63	1.15	0.66	11.73	18.60	7.69	2.19	5.65	5.61	1.88	1.97	4.69	1.33	0.89	1.08
23	I2_SR1	SilentIntronRegion	0	1.88	1.24	0.69	1.58	2.66	1.25	3.72	1.17	0.63	1.15	0.66	11.73	18.62	7.70	2.19	5.66	5.62	1.89	1.97	4.70	1.33	0.89	1.08
24	E3_Aa	NovelBoundary	0	0.00	2.76	0.00	2.06	0.00	0.00	0.00	0.00	0.00	0.00	0.00	18.31	19.32	12.48	4.94	11.79	14.31	0.00	4.05	5.43	3.15	0.00	7.51
25	ER3a	ExonRegion	0	5.47	12.44	5.60	22.50	16.07	21.31	12.43	4.26	5.60	17.19	6.49	34.18	42.95	38.82	22.96	26.07	23.18	14.08	14.34	26.19	18.34	5.97	16.09
26	E3_Da	NovelBoundary	0	0.00	0.00	0.00	1.60	7.22	8.35	0.00	0.00	0.00	1.32	0.00	26.26	21.75	18.48	0.00	8.12	0.00	0.00	0.00	6.39	0.00	0.00	0.00
27	E3a_E4a	KnownJunction	0	7.56	6.18	1.12	16.18	7.72	4.88	6.36	4.39	0.00	7.39	4.42	18.91	0.00	18.72	4.45	0.00	20.38	1.58	4.80	11.44	2.84	0.00	3.67
28	E3a_E4b	KnownJunction	0	0.00	12.76	6.68	8.32	15.20	31.91	4.02	2.55	1.22	8.92	0.00	51.02	21.26	10.30	0.00	17.60	17.67	4.77	8.47	2.43	2.84	5.14	4.01
29	I3	Intron	0	2.76	5.94	1.31	5.36	3.83	6.44	6.50	2.80	1.94	2.50	1.86	22.34	31.86	12.56	4.47	6.56	5.03	2.98	4.06	9.59	1.30	2.53	1.83
30	I3_SR1	SilentIntronRegion	0	2.76	5.94	1.31	5.37	3.83	6.45	6.51	2.80	1.95	2.50	1.86	22.36	31.88	12.57	4.47	6.56	5.03	2.98	4.06	9.59	1.30	2.53	1.83
31	E4_Aa	NovelBoundary	1	3.78	2.83	1.83	9.69	12.31	2.78	5.96	2.46	1.79	9.67	0.00	12.45	90.90	36.85	5.69	16.15	16.46	4.31	8.09	20.52	2.41	11.27	4.35
32	ER4a	ExonRegion	0	34.95	16.46	3.60	30.46	18.44	32.85	10.27	10.95	7.10	13.82	7.99	31.51	59.08	44.77	22.48	27.65	32.32	13.73	16.01	26.41	14.50	9.19	8.09
33	E4_Ab	KnownBoundary	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
34	E4a_E4b	NovelJunction	0	37.12	19.01	2.87	29.53	13.92	19.93	17.75	4.97	5.84	16.14	9.58	82.98	68.66	39.67	19.04	43.83	17.77	15.67	0.00	39.37	7.48	2.76	11.18
35	E4_Da	KnownBoundary	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
36	E4a_E5a	KnownJunction	0	2.74	0.00	1.39	8.69	0.00	0.00	4.42	0.00	0.00	3.09	0.00	0.00	8.28	2.18	9.64	0.00	9.07	0.00	0.00	2.56	0.00	0.00	0.00
37	ER4b	ExonRegion	0	25.40	24.40	12.25	32.71	26.76	42.18	23.83	6.91	8.65	25.23	17.40	108.24	89.11	55.22	26.11	56.47	46.21	14.78	25.48	40.43	19.83	12.50	14.68
38	ER4c	ExonRegion	1	32.41	24.18	10.23	30.50	38.46	47.73	20.03	13.90	6.77	22.56	13.61	64.97	115.75	78.08	32.23	58.50	46.89	26.72	32.01	36.81	24.56	15.78	14.65
39	E4_Db	NovelBoundary	0	3.78	21.25	20.52	22.71	18.68	13.34	40.14	10.06	9.43	21.87	10.42	55.07	97.07	43.26	24.85	27.34	50.12	17.91	17.79	28.70	10.38	8.33	15.11
40	E4b_E5a	KnownJunction	0	14.00	14.21	13.04	20.01	43.12	55.08	20.14	10.60	9.43	12.71	0.00	5.85	43.18	55.74	21.14	47.00	17.77	18.70	26.54	28.63	17.30	11.08	8.28
41	E4b_E8b	NovelJunction	0	17.86	0.00	0.00	2.96	0.00	0.00	0.00	0.00	0.00	0.00	5.00	6.30	6.82	14.83	0.00	8.63	12.44	1.78	0.00	0.00	5.62	0.00	4.35
42	E4b_E10a	NovelJunction	0	0.00	0.00	0.00	2.06	0.00	0.00	0.00	0.00	0.00	1.29	0.00	0.00	0.00	4.94	4.45	12.99	0.00	0.00	0.00	3.26	0.00	0.00	0.00
43	I4	Intron	0	15.38	13.09	3.95	14.65	15.59	18.52	14.62	7.86	5.41	6.92	4.51	28.01	49.12	26.48	18.57	14.51	16.67	5.67	9.01	20.54	3.67	7.98	3.59
44	I4_SR1	SilentIntronRegion	0	15.42	13.12	3.96	14.68	15.63	18.56	14.65	7.88	5.43	6.94	4.52	28.07	49.22	26.54	18.60	14.55	16.70	5.68	9.03	20.59	3.67	8.00	3.59
45	E5_Aa	NovelBoundary	0	3.63	24.47	1.83	7.39	20.63	27.82	20.89	4.64	7.26	6.02	5.37	37.36	19.64	23.66	33.01	3.76	8.79	3.69	4.80	29.59	3.03	9.00	0.00
46	ER5a	ExonRegion	0	40.30	40.59	21.82	36.96	63.17	56.42	27.18	20.98	14.38	27.45	13.40	62.24	77.96	63.15	63.39	39.17	37.85	17.43	38.81	29.70	14.84	19.64	13.46
47	E5_Da	NovelBoundary	0	0.00	9.41	1.54	1.63	10.36	17.38	2.16	2.26	1.24	1.40	0.00	18.91	35.55	15.77	4.45	11.96	7.48	16.58	0.00	17.90	0.00	5.33	0.00
48	E5a_E6a	KnownJunction	0	18.97	14.67	8.40	5.89	30.31	31.52	2.21	5.09	7.23	11.63	2.26	25.21	20.62	9.65	6.30	7.09	0.00	4.19	11.67	15.40	0.00	5.39	4.35
49	E5a_E8b	KnownJunction	0	45.19	8.62	12.15	14.58	50.34	61.16	14.79	14.13	9.20	9.32	2.21	7.65	21.91	16.78	55.26	43.15	24.31	6.14	11.86	11.19	0.00	5.69	23.73
50	E5a_E10a	NovelJunction	0	5.63	0.00	1.42	1.86	7.22	0.00	0.00	0.00	1.74	5.10	2.42	6.00	6.82	10.01	8.90	0.00	8.04	1.58	0.00	5.62	0.00	0.00	0.00
51	I5	Intron	0	6.82	8.09	2.02	8.18	15.63	9.28	9.63	3.18	4.08	6.32	3.11	17.94	34.79	15.82	8.31	11.37	10.72	7.61	9.78	14.73	5.44	5.09	3.55
52	I5_SR1	SilentIntronRegion	0	2.36	4.83	0.80	4.37	11.32	7.86	7.67	1.79	1.90	3.90	0.75	5.25	16.84	8.05	5.12	10.66	5.01	4.77	7.38	12.87	5.77	2.41	1.83
53	I5_AR1	ActiveIntronRegion	0	5.77	5.42	1.21	7.30	11.60	8.34	5.80	3.36	3.75	8.04	4.39	13.80	17.05	20.80	9.72	12.11	13.41	5.89	10.00	13.77	6.76	3.89	3.26
54	I5_SR2	SilentIntronRegion	0	8.07	9.83	2.59	9.24	18.16	9.95	11.66	3.34	4.61	6.01	2.98	21.98	45.71	15.04	8.27	11.20	10.56	8.87	10.12	15.50	4.81	6.09	3.98
55	E6_Aa	NovelBoundary	0	14.08	18.62	5.65	18.31	21.73	17.43	11.53	3.41	7.35	23.96	5.11	12.60	46.43	24.84	0.00	11.54	12.62	4.44	18.07	33.88	3.09	23.64	0.00
56	ER6a	ExonRegion	0	36.30	28.33	14.37	30.92	36.97	43.82	18.95	12.76	11.92	26.99	6.89	53.67	56.17	35.40	19.22	27.33	18.63	8.62	19.99	28.61	10.20	14.39	11.02
57	E6_Da	KnownBoundary	0	49.49	27.82	13.36	33.73	34.89	23.57	20.18	6.78	10.42	18.05	4.63	36.16	59.74	31.49	5.69	40.67	16.46	4.56	3.58	31.77	4.82	21.55	17.16
58	ER6b	ExonRegion	0	28.51	21.09	7.35	15.93	22.67	20.93	10.83	2.78	5.26	11.00	3.52	23.85	40.46	26.15	10.07	29.49	8.74	2.54	5.56	19.82	8.51	15.69	6.28
59	E6_Db	NovelBoundary	0	17.86	6.64	3.02	27.10	28.35	12.61	24.95	11.67	4.89	16.68	5.37	57.32	38.80	19.60	0.00	11.88	9.16	1.70	12.99	20.90	6.30	18.37	11.61
60	E6b_E7a	KnownJunction	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.58	0.00	0.00	0.00	5.47	4.70	0.00	4.68	0.00	0.00	0.00	0.00	0.00	0.00
61	E6b_E8b	KnownJunction	0	10.52	6.31	5.91	3.76	19.61	24.30	6.27	0.00	3.01	5.67	0.00	0.00	0.00	2.41	4.45	0.00	4.68	0.00	7.72	3.20	3.09	0.00	4.35
62	I6	Intron	0	19.23	19.62	7.55	17.69	22.97	14.36	11.12	4.68	4.50	13.28	5.21	29.22	31.68	15.35	7.26	9.68	7.86	12.50	15.97	17.73	6.90	8.75	6.81
63	I6_AR1	ActiveIntronRegion	0	20.26	20.83	8.06	18.89	24.36	15.34	11.87	5.00	4.80	14.18	5.56	28.63	32.29	16.04	7.16	10.34	8.40	13.35	16.63	18.80	7.23	9.20	7.27
64	I6_SR1	SilentIntronRegion	1	4.15	1.96	0.00	0.00	2.62	0.00	0.00	0.00	0.00	0.00	0.00	37.80	22.73	5.18	8.76	0.00	0.00	0.00	6.25	2.09	2.08	2.04	0.00
65	E7_Aa	NovelBoundary	0	32.38	35.26	1.83	6.99	34.13	2.73	20.01	5.13	7.67	8.54	0.00	17.56	47.56	29.78	13.60	7.60	7.67	24.62	4.80	27.48	12.85	12.31	8.54
66	ER7a	ExonRegion	0	19.94	30.08	3.33	12.93	17.71	14.87	11.38	4.28	4.81	8.45	6.43	31.24	54.81	35.97	18.63	16.32	9.17	20.87	20.03	19.04	9.31	11.68	9.98
67	E7_Da	NovelBoundary	0	3.78	71.04	5.62	22.14	31.24	7.67	18.55	2.42	4.02	14.53	7.53	11.70	19.48	12.42	0.00	19.40	4.77	20.77	3.67	14.89	8.53	22.66	0.00
68	E7a_E8b	KnownJunction	0	0.00	0.00	0.00	1.90	12.48	0.00	0.00	2.38	0.00	1.45	10.11	0.00	0.00	2.41	0.00	0.00	0.00	2.49	0.00	5.56	0.00	3.12	0.00
69	I7	Intron	0	26.91	44.43	7.47	30.57	30.69	17.82	20.22	10.92	5.38	17.60	3.25	26.13	41.12	17.50	7.94	14.55	9.89	6.05	22.58	12.13	2.74	10.97	5.79
70	I7_SR1	SilentIntronRegion	0	20.13	42.41	5.86	24.33	17.32	9.21	14.47	14.58	5.26	14.87	2.77	11.29	36.88	16.25	6.15	16.59	7.82	8.66	19.36	15.13	2.36	11.12	9.15
71	I7_AR1	ActiveIntronRegion	0	31.73	46.05	8.63	35.04	40.12	23.88	24.30	8.43	5.49	19.59	3.60	36.54	44.26	18.45	9.23	13.20	11.37	4.28	24.92	10.09	3.01	10.92	3.49
72	E8_Aa	NovelBoundary	0	35.86	31.31	20.16	57.80	27.16	13.74	26.98	10.51	7.58	22.13	4.79	24.61	6.33	26.13	15.45	15.72	4.77	5.31	26.54	16.62	0.00	17.45	0.00
73	ER8a	ExonRegion	0	76.91	80.08	27.53	65.96	54.51	36.14	32.04	17.21	8.47	27.27	6.00	40.84	60.68	23.71	22.88	17.93	14.32	21.49	28.10	20.73	8.47	14.27	10.60
74	E8_Ab	KnownBoundary	0	82.01	69.92	39.35	77.68	74.45	51.45	55.16	17.91	16.41	39.22	9.53	27.61	66.88	23.90	47.59	14.70	15.80	7.63	37.93	25.31	6.24	10.96	3.59
75	ER8b	ExonRegion	0	170.96	130.52	63.66	92.74	190.22	153.12	67.22	40.54	25.94	53.49	24.86	73.99	132.81	93.46	112.36	64.58	70.52	15.45	87.60	51.84	21.74	34.09	27.50
76	ER8c	ExonRegion	0	142.62	96.67	42.26	93.41	93.06	97.49	44.32	35.29	24.27	43.23	23.90	79.36	104.37	81.08	103.01	47.19	50.49	24.55	75.78	43.75	25.26	34.18	26.62
77	E8b_E9a	KnownJunction	0	0.00	3.35	1.33	7.39	12.22	2.67	6.40	2.22	0.00	1.56	2.42	0.00	6.82	5.36	4.57	0.00	0.00	4.73	0.00	0.00	0.00	0.00	3.84
78	E8b_E10a	KnownJunction	0	165.36	60.12	16.79	86.70	70.88	105.56	53.22	40.62	17.25	28.58	26.11	45.31	108.76	74.93	143.64	47.51	12.25	23.63	46.50	42.31	22.36	29.45	22.79
79	E9_Aa	NovelBoundary	0	25.34	0.00	0.00	10.16	4.33	2.73	4.50	4.35	5.87	2.63	0.00	0.00	0.00	7.59	0.00	4.19	0.00	7.42	0.00	12.08	0.00	0.00	0.00
80	ER9a	ExonRegion	0	9.18	6.39	1.95	9.85	14.57	4.17	4.32	2.69	0.00	2.42	1.82	1.72	14.69	9.12	8.18	4.29	6.32	0.99	0.03	4.13	1.06	2.61	0.39
81	E9_Da	NovelBoundary	0	13.71	8.75	1.63	7.36	31.58	2.90	4.28	0.00	3.15	8.43	0.00	11.85	37.98	16.54	10.38	8.72	11.78	15.67	9.60	2.81	2.90	0.00	0.00
82	E9a_E10a	KnownJunction	0	3.56	0.00	0.00	2.96	0.00	0.00	0.00	2.18	0.00	1.48	2.16	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	3.06	0.00
83	I9	Intron	0	33.97	8.58	4.08	17.97	28.11	8.87	9.15	6.39	2.44	6.78	3.52	6.92	23.78	12.26	15.74	6.52	4.64	2.05	3.03	2.29	1.82	3.71	2.06
84	I9_AR1	ActiveIntronRegion	0	30.96	8.34	2.62	15.45	30.26	11.38	11.33	5.58	2.75	7.23	5.72	8.32	33.98	18.61	15.68	11.23	5.86	3.10	5.29	3.55	3.29	3.37	3.05
85	I9_SR2	SilentIntronRegion	0	40.32	9.09	5.74	21.97	28.62	7.89	8.55	7.86	2.52	7.35	2.47	6.33	17.39	8.50	16.17	4.05	4.05	1.63	1.31	1.56	1.02	3.84	1.66
86	I9_AR2	ActiveIntronRegion	0	13.89	7.01	1.54	7.91	17.03	3.86	3.41	2.17	0.78	2.16	0.00	4.29	15.35	5.89	13.93	0.07	2.78	0.00	2.69	0.90	0.00	4.39	0.17
87	E10_Aa	NovelBoundary	0	45.34	15.39	6.50	21.94	15.79	2.44	5.70	7.27	2.98	10.96	0.00	0.00	0.00	2.47	22.99	8.54	0.00	0.00	0.00	5.88	0.00	5.69	7.09
88	ER10a	ExonRegion	0	101.49	47.94	44.61	96.24	71.61	64.40	32.65	44.79	29.36	54.09	25.01	53.83	64.75	76.91	133.58	47.41	49.80	16.70	56.86	43.74	24.94	50.30	17.59
89	E10_Da	KnownBoundary	0	133.36	30.85	27.05	47.55	145.67	41.96	30.38	23.70	10.45	23.50	5.32	51.62	60.87	54.86	75.65	30.42	16.83	10.57	23.25	18.09	9.14	37.84	8.19
90	ER10b	ExonRegion	0	57.12	14.55	18.03	29.38	51.64	19.21	18.79	14.13	2.59	17.13	2.43	33.19	41.22	26.22	51.77	10.24	7.12	6.69	9.84	12.17	1.89	9.05	1.11
91	ER10c	ExonRegion	0	15.87	2.03	0.00	4.77	10.70	1.83	9.93	0.00	0.00	5.16	0.00	0.00	4.69	5.68	11.61	0.00	3.30	0.00	3.19	0.00	0.00	0.00	0.00
92	ER10d	ExonRegion	0	4.23	2.03	0.00	2.04	5.35	0.92	1.32	0.00	0.00	2.29	0.00	0.00	0.00	2.44	5.80	0.00	3.30	0.00	3.19	0.00	0.00	0.00	0.00