Order	SeqName	SeqType	IsAE	NBL01_MYCN	NBL05_MYCN	NBL09_MYCN	NBL10_MYCN	NBL02	NBL03	NBL04	NBL06	NBL07	NBL08	NBL11_Rel2	NBL11_Rem1	NBL11_Rel1	NBL12_Rel_Left	NBL12_Rel_Right	NBL13_Rel_Left	NBL13_Rel_Right	NBL14_MYCN_Met	NBL14_MYCN_Pri	NBL15_MYCN_Rel1	SKP01	SKP02	SKP03
1	DHRS12	Gene	0	18.04	14.53	23.07	17.87	21.33	30.06	12.61	27.28	26.37	22.33	10.49	11.09	7.01	12.90	13.36	11.31	10.80	17.35	17.79	19.55	10.58	6.87	6.20
2	490949	Transcript	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
3	218981	Transcript	0	17.08	12.10	23.76	18.12	13.88	27.17	9.46	20.86	20.27	20.35	4.20	2.15	2.93	6.11	7.93	7.62	8.24	23.16	12.75	16.03	6.45	5.43	4.64
4	444610	Transcript	0	10.86	9.04	22.50	22.52	21.33	12.36	8.52	42.53	18.88	13.80	5.76	6.00	0.00	19.42	13.21	4.23	3.85	8.17	15.91	10.61	2.93	6.00	4.18
5	280056	Transcript	0	5.80	5.58	5.02	4.29	6.92	8.99	4.23	6.34	7.20	6.82	3.11	2.70	1.78	2.77	2.64	2.34	2.69	5.55	4.22	5.64	5.81	1.94	1.78
6	497151	Transcript	0	0.00	0.00	1.57	0.00	3.03	2.18	1.12	2.63	2.10	1.47	0.54	1.00	0.00	0.16	0.41	0.00	0.47	4.47	0.45	1.80	0.00	0.29	0.00
7	489680	Transcript	0	4.71	2.76	4.03	4.66	3.69	2.07	0.69	2.87	1.00	3.69	2.46	5.26	0.00	4.24	4.25	7.32	3.49	3.88	3.49	7.27	3.30	2.08	0.70
8	461948	Transcript	0	4.90	5.79	6.42	11.55	5.60	7.44	6.31	8.65	9.30	5.58	2.39	4.48	8.39	2.32	1.40	1.98	4.96	13.01	7.79	8.20	5.67	0.59	12.56
9	472372	Transcript	0	11.42	6.92	6.90	5.16	11.53	18.01	4.61	9.35	9.15	10.49	3.88	12.41	1.45	3.78	3.17	3.94	3.45	7.91	6.83	5.46	3.00	5.22	4.22
10	469957	Transcript	0	5.20	4.10	4.27	10.06	5.48	8.53	6.63	5.74	16.42	7.65	2.07	9.47	3.27	2.14	3.33	3.46	4.57	3.99	6.72	8.44	1.33	4.50	0.68
11	ER1a	ExonRegion	0	25.64	15.16	3.54	2.41	18.27	37.10	13.47	2.91	9.28	1.08	16.40	0.00	0.00	7.19	9.20	11.89	17.45	6.18	13.92	17.75	20.27	3.10	12.67
12	E1_Ab	KnownBoundary	0	66.75	35.26	17.30	6.19	51.36	103.46	33.92	9.00	14.87	10.72	35.11	0.00	0.00	14.36	19.53	42.98	40.49	17.41	31.34	53.82	30.77	8.51	24.41
13	E1_Ac	KnownBoundary	0	36.52	38.22	4.76	9.22	37.18	88.93	32.28	14.09	36.57	19.66	17.64	0.00	6.01	26.90	15.20	19.40	18.51	49.25	8.85	27.36	8.59	0.00	8.19
14	ER1b	ExonRegion	0	34.29	30.10	5.20	7.36	35.00	75.99	26.90	9.54	26.53	9.22	24.35	0.00	0.00	16.50	17.64	21.76	27.99	27.57	18.73	36.26	22.21	3.67	15.15
15	ER1c	ExonRegion	0	20.88	47.47	6.32	9.11	27.00	57.26	14.29	11.63	28.24	22.76	7.20	1.67	0.32	11.74	8.44	9.19	8.48	23.10	4.13	16.68	6.21	0.28	5.07
16	E1_Da	NovelBoundary	0	0.00	0.00	3.31	0.00	0.00	0.00	0.00	0.00	6.19	4.30	0.00	0.00	0.00	6.53	0.00	3.76	3.74	10.65	13.46	8.95	6.30	6.25	0.00
17	E1a_E3a	KnownJunction	0	9.78	41.64	9.91	6.86	11.46	22.88	4.42	8.67	12.09	27.69	2.21	6.30	0.00	2.47	4.45	0.00	0.00	6.51	0.00	2.49	5.50	0.00	0.00
18	ER2a	ExonRegion	0	0.00	0.00	1.34	0.00	1.82	1.97	2.24	1.12	3.02	1.62	1.09	2.01	0.00	0.32	0.82	0.00	0.93	4.04	0.90	3.61	0.00	0.59	0.00
19	E2_Da	NovelBoundary	0	0.00	0.00	1.21	0.00	0.00	0.00	2.25	0.00	3.15	0.00	7.58	0.00	0.00	2.47	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
20	E2a_E3a	KnownJunction	0	0.00	0.00	1.80	0.00	4.24	2.38	0.00	4.15	1.19	1.32	0.00	0.00	0.00	0.00	0.00	0.00	0.00	4.89	0.00	0.00	0.00	0.00	0.00
21	ER3a	ExonRegion	0	10.99	14.93	20.77	17.80	26.06	22.81	12.59	39.74	37.74	30.55	25.79	11.53	4.83	20.03	17.60	21.71	21.70	10.89	28.29	36.46	23.78	9.03	10.80
22	E3a_E4a	KnownJunction	0	6.30	9.27	5.82	1.73	8.66	2.38	2.21	24.81	30.29	9.40	11.95	0.00	12.01	19.01	31.89	27.09	12.16	26.94	0.00	17.96	3.15	3.12	15.71
23	E3a_E5a	KnownJunction	0	3.63	6.71	36.49	24.31	36.08	31.06	1.94	39.39	18.46	40.19	5.32	30.31	13.31	19.48	9.64	36.57	4.77	21.80	26.45	35.73	16.19	8.51	28.08
24	ER4a	ExonRegion	0	7.65	11.00	11.62	6.65	6.93	10.43	7.21	29.72	39.75	7.48	10.08	13.25	21.13	17.42	25.87	15.22	9.15	11.58	5.83	16.74	5.73	5.77	5.98
25	E4a_E5a	KnownJunction	0	0.00	5.99	17.71	14.88	12.14	13.17	20.84	32.08	40.22	7.01	24.43	16.96	12.82	20.60	23.98	8.46	9.35	5.93	3.48	14.32	9.33	5.94	0.00
26	ER5a	ExonRegion	0	21.60	18.72	51.82	40.83	74.26	75.50	34.72	83.02	71.32	47.11	38.87	35.94	30.81	48.41	28.83	36.50	28.82	22.37	40.42	42.21	27.04	12.68	19.17
27	E5_Da	NovelBoundary	0	20.60	2.50	2.96	7.72	16.98	14.08	5.87	7.27	6.48	8.19	0.00	18.01	0.00	0.00	0.00	0.00	4.39	5.14	4.61	5.43	0.00	2.45	6.57
28	E5a_E6a	KnownJunction	0	45.12	28.28	64.28	39.89	86.76	138.56	46.55	80.83	73.03	47.22	35.38	12.30	73.05	55.74	38.45	43.41	13.09	23.17	25.51	41.42	22.73	30.98	25.52
29	E6_Ac	NovelBoundary	0	45.56	25.00	44.23	25.07	60.44	87.28	29.77	51.92	45.49	52.27	31.32	37.81	27.60	24.43	34.86	24.10	17.02	21.60	48.19	33.11	29.96	15.31	12.04
30	ER6a	ExonRegion	0	36.73	24.52	53.63	33.35	72.56	121.03	44.24	72.09	69.75	47.50	39.45	22.41	77.80	61.14	36.69	49.48	11.65	28.91	38.97	43.43	26.44	30.52	23.32
31	ER6b	ExonRegion	0	40.67	24.11	59.17	31.25	75.49	127.32	41.52	70.87	64.93	47.92	41.83	41.13	62.65	55.22	35.64	43.10	17.92	27.58	53.24	42.40	26.60	28.72	19.30
32	ER6c	ExonRegion	0	43.36	30.92	52.31	24.92	43.77	75.42	33.03	62.49	52.86	48.64	45.40	68.05	31.51	40.23	32.51	35.59	28.35	19.05	40.84	36.55	22.32	20.46	8.81
33	E6_Da	NovelBoundary	0	28.15	18.35	29.98	15.02	10.02	31.29	28.93	26.53	26.39	16.20	31.96	23.56	6.98	22.72	31.52	21.36	23.38	6.59	11.29	20.01	5.31	15.00	3.41
34	E6b_E8a	KnownJunction	0	44.75	57.69	51.74	24.71	39.98	46.90	17.71	65.14	42.27	42.47	37.96	46.52	5.84	36.61	38.20	43.41	16.08	22.09	28.14	14.19	26.32	13.29	15.02
35	ER6d	ExonRegion	0	31.75	43.72	44.93	22.71	33.00	37.90	20.52	58.48	42.61	43.58	37.53	51.23	9.38	36.95	39.41	36.41	28.33	18.79	19.11	22.69	22.59	15.11	11.99
36	I6	Intron	0	4.77	6.49	3.79	5.81	12.90	13.48	10.43	8.24	17.28	10.38	4.97	15.35	11.31	9.84	3.49	7.56	7.31	13.12	12.47	17.34	5.62	4.88	6.06
37	I6_SR1	SilentIntronRegion	0	2.62	3.66	2.27	3.17	7.32	9.00	8.32	4.93	12.45	7.39	4.40	14.19	9.03	9.76	3.55	6.33	7.72	11.68	11.19	15.61	4.77	3.65	5.72
38	I6_AR1	ActiveIntronRegion	0	11.97	15.85	6.31	13.98	24.90	27.02	20.52	11.03	37.04	16.55	6.23	28.00	27.46	11.24	3.07	13.61	5.45	9.68	18.33	22.31	8.17	7.26	7.46
39	I6_SR2	SilentIntronRegion	0	9.13	19.16	4.79	10.09	41.59	36.38	24.60	16.25	27.55	14.88	4.44	33.46	30.87	11.14	3.22	13.45	9.11	15.34	21.79	26.86	6.70	8.53	11.70
40	I6_AR2	ActiveIntronRegion	0	6.74	7.23	5.83	11.57	13.87	14.60	7.23	10.19	20.24	17.29	7.62	12.07	6.85	10.86	3.80	12.84	7.10	20.88	11.14	22.28	7.62	7.71	4.94
41	I6_SR3	SilentIntronRegion	0	12.07	10.71	11.36	13.40	23.80	21.37	15.11	19.72	33.05	16.15	8.67	7.80	7.92	9.73	2.95	11.26	9.64	18.62	18.73	25.62	10.61	7.28	5.96
42	I6_AR3	ActiveIntronRegion	0	8.08	8.59	7.43	9.99	16.51	17.75	8.97	15.00	25.70	19.31	5.34	10.76	10.16	8.72	3.92	4.42	4.35	16.55	11.69	13.79	6.31	4.94	4.42
43	I6_SR4	SilentIntronRegion	0	4.86	7.25	4.28	5.89	13.17	6.98	6.89	13.52	13.00	9.66	4.94	7.76	4.81	7.91	2.98	3.43	1.78	12.39	3.37	10.77	3.89	8.62	3.83
44	E7_Aa	NovelBoundary	0	20.45	31.90	20.73	19.41	24.19	38.61	22.30	19.84	35.97	16.01	0.00	25.21	13.80	7.06	14.09	4.36	9.26	2.11	8.28	17.19	10.87	2.39	7.00
45	ER7a	ExonRegion	0	19.86	17.52	12.05	10.98	23.70	35.22	14.75	16.93	21.01	18.00	8.05	28.99	5.79	8.39	4.05	9.27	8.31	11.26	14.59	14.80	3.69	2.93	4.25
46	E7_Da	NovelBoundary	0	10.45	16.58	15.20	11.89	12.05	13.06	1.81	14.38	35.62	9.48	2.63	12.60	0.00	21.78	8.90	4.36	13.56	29.93	8.09	16.94	11.18	0.00	0.00
47	E7a_E8a	KnownJunction	0	16.45	2.96	7.63	8.59	7.81	5.62	0.00	7.52	4.48	9.83	7.48	0.00	0.00	3.00	0.00	4.19	3.65	9.99	0.00	3.00	2.97	0.00	0.00
48	I7	Intron	0	5.35	2.57	9.24	3.42	10.15	10.05	2.79	5.43	6.21	6.48	0.81	7.51	0.00	3.87	2.95	7.52	2.78	8.90	14.77	8.07	3.70	1.76	2.48
49	I7_AR1	ActiveIntronRegion	0	5.44	2.61	9.39	3.47	10.32	10.22	2.84	5.52	6.30	6.59	0.83	7.64	0.00	3.93	3.00	7.62	2.83	9.02	15.02	8.17	3.76	1.79	2.52
50	E8_Aa	NovelBoundary	0	13.11	24.21	16.17	11.02	16.98	17.15	6.01	26.45	27.20	13.65	5.00	0.00	6.17	13.83	0.00	15.04	8.32	39.96	12.71	34.71	9.02	8.57	7.85
51	ER8a	ExonRegion	0	49.94	52.71	57.04	31.52	42.29	58.92	17.08	56.54	48.23	43.86	37.44	46.23	29.43	34.94	43.94	24.69	32.00	30.91	29.95	33.32	28.79	13.27	16.29
52	E8_Da	NovelBoundary	0	2.96	9.01	4.76	4.13	7.89	18.11	5.56	4.15	17.53	5.35	2.26	17.71	0.00	15.07	10.38	4.19	8.13	16.79	17.32	2.49	12.48	5.63	0.00
53	E8a_E9a	KnownJunction	0	3.33	0.00	4.58	3.46	0.00	0.00	0.00	4.23	0.00	2.98	2.05	0.00	0.00	4.94	0.00	3.85	0.00	5.97	0.00	6.14	0.00	0.00	0.00
54	E8a_E10b	KnownJunction	0	46.82	39.86	51.18	31.83	57.72	42.13	22.04	43.83	51.42	48.22	37.27	6.30	34.41	38.44	30.41	11.45	7.57	24.71	31.72	26.33	17.30	11.82	15.28
55	E9_Aa	NovelBoundary	0	7.11	6.51	10.91	12.15	12.31	18.06	0.00	8.13	17.30	13.57	5.00	6.15	7.63	9.83	4.45	12.05	0.00	8.54	26.26	24.74	14.27	0.00	4.35
56	ER9a	ExonRegion	0	3.90	2.09	4.51	4.86	6.75	3.32	2.07	1.93	1.58	3.87	3.00	9.91	0.00	5.30	6.56	10.34	5.79	5.68	5.68	12.49	9.90	0.97	2.09
57	E9_Da	NovelBoundary	0	6.30	0.00	16.68	13.92	3.23	13.40	12.67	3.24	12.01	8.22	0.00	12.60	0.00	4.94	0.00	7.69	8.51	21.60	17.88	8.50	7.97	2.88	3.50
58	E9a_E10b	KnownJunction	0	6.89	6.18	2.99	5.66	4.33	2.90	0.00	2.46	1.42	4.22	2.32	5.85	0.00	2.47	6.18	7.78	4.68	0.00	4.80	3.20	0.00	5.27	0.00
59	E10_Aa	NovelBoundary	0	14.00	15.19	16.85	25.57	16.38	44.07	28.26	28.79	53.18	26.73	4.84	18.46	34.09	9.65	8.90	13.67	3.65	13.89	18.45	20.90	5.93	10.96	16.22
60	ER10a	ExonRegion	0	10.40	8.20	8.54	20.13	10.97	17.07	13.25	9.06	32.83	15.30	4.14	18.94	6.55	4.28	6.66	6.92	9.14	5.95	13.44	16.88	2.66	9.00	1.36
61	E10_Ab	KnownBoundary	0	6.22	17.76	13.57	40.52	27.59	36.17	14.71	23.17	49.31	23.91	9.48	18.91	6.01	2.47	0.00	12.56	13.84	7.83	18.82	16.23	2.29	7.78	4.01
62	ER10b	ExonRegion	0	59.18	45.46	72.20	59.70	81.89	96.98	38.64	76.40	75.32	79.16	40.94	47.37	32.24	45.62	40.98	38.21	31.45	41.91	64.78	53.95	35.70	23.10	21.21
63	E10_Da	NovelBoundary	0	2.96	0.00	3.02	1.23	3.14	9.03	5.39	5.38	14.44	3.17	0.00	18.91	0.00	0.00	4.45	3.25	0.00	4.23	7.53	8.31	3.09	4.96	11.78
64	E10a_E11a	KnownJunction	0	3.48	0.00	3.96	11.65	0.00	5.79	3.84	6.61	5.15	4.16	2.68	0.00	13.64	2.24	0.00	0.00	3.55	14.18	4.24	6.26	3.15	0.00	19.38
65	E10a_E12a	KnownJunction	1	57.20	18.62	85.36	23.94	43.55	77.46	30.65	65.96	49.71	56.62	29.11	30.01	6.01	22.90	59.83	32.04	15.80	27.36	40.94	39.18	24.83	13.41	3.59
66	E10a_E14a	NovelJunction	0	3.78	0.00	8.81	4.13	11.12	5.62	1.90	3.53	9.14	4.49	0.00	6.30	6.82	4.94	8.90	8.12	4.30	4.64	16.57	0.00	3.15	2.45	0.00
67	E10_Db	NovelBoundary	0	7.56	0.00	3.49	3.03	3.23	5.00	0.00	2.55	13.37	0.00	5.11	19.06	5.84	0.00	0.00	0.00	13.84	6.26	0.00	6.01	0.00	0.00	0.00
68	E10b_E12a	KnownJunction	0	3.26	3.35	3.43	0.00	8.06	16.52	0.00	6.98	4.77	6.37	0.00	12.00	0.00	2.12	4.45	0.00	0.00	6.72	0.00	0.00	3.15	8.45	6.74
69	ER10c	ExonRegion	0	6.11	3.84	4.49	1.06	6.54	14.67	3.68	5.95	6.31	7.77	0.00	8.66	0.00	1.62	4.19	2.31	1.83	3.70	12.74	4.02	2.20	9.49	5.87
70	E11_Aa	NovelBoundary	0	10.45	0.00	0.00	9.16	21.48	0.00	14.79	10.10	17.68	5.78	0.00	6.30	13.15	7.12	0.00	0.00	0.00	4.52	0.00	9.14	0.00	5.69	0.00
71	ER11a	ExonRegion	0	6.32	11.58	8.87	11.44	11.20	9.09	8.77	10.68	13.46	7.00	2.09	8.97	3.15	2.41	2.80	3.96	6.37	11.84	11.35	10.13	8.18	1.19	5.74
72	E11_Da	NovelBoundary	0	6.74	14.80	8.69	9.36	15.70	35.04	16.52	19.59	16.06	7.39	5.05	0.00	20.45	0.00	5.44	12.13	13.46	6.63	35.39	8.44	5.44	4.96	0.00
73	I11_AR1	ActiveIntronRegion	0	5.72	12.27	6.95	11.78	13.40	9.86	8.84	11.46	18.62	14.74	2.80	6.38	2.35	5.34	4.05	0.00	2.72	10.70	13.75	5.95	4.93	2.63	5.05
74	ER12a	ExonRegion	0	51.24	22.21	58.04	33.68	46.16	72.65	23.76	67.75	52.84	47.97	21.52	23.07	3.50	28.47	41.67	26.00	16.69	37.42	44.84	36.24	22.21	13.00	14.65
75	E12_Da	NovelBoundary	0	0.00	12.70	7.84	12.29	0.00	2.21	13.51	5.71	7.52	8.38	4.79	0.00	0.00	2.41	0.00	12.13	0.00	15.05	0.00	8.82	0.00	5.76	8.71
76	E12a_E13a	KnownJunction	0	3.78	3.35	0.00	0.00	3.74	0.00	0.00	2.34	1.79	1.67	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	5.19	0.00	0.00
77	E12a_E14a	KnownJunction	0	34.45	20.98	30.75	32.43	50.76	62.98	39.88	63.17	47.51	21.44	15.58	17.71	0.00	14.36	27.44	13.24	8.32	30.51	27.39	28.51	21.93	2.57	10.93
78	E13_Aa	NovelBoundary	0	6.59	6.18	9.96	12.59	11.21	0.00	12.06	18.28	9.95	16.31	2.68	0.00	0.00	2.47	0.00	0.00	12.72	11.61	9.60	15.28	8.96	3.12	4.18
79	ER13a	ExonRegion	0	7.81	7.80	10.05	8.58	10.11	17.99	8.45	10.33	12.60	11.97	6.22	5.40	3.56	5.55	5.29	4.68	5.38	11.10	8.44	11.27	6.44	3.88	3.56
80	ER14a	ExonRegion	0	21.63	20.47	34.27	28.20	25.98	31.59	15.56	62.51	36.50	32.48	10.25	8.28	5.61	27.40	30.13	10.47	10.38	24.70	28.85	25.95	16.27	12.70	6.75
81	E14_Da	KnownBoundary	0	16.30	9.67	15.37	12.75	24.45	22.83	11.84	15.40	7.73	14.08	2.05	0.00	0.00	7.06	4.45	0.00	8.32	30.47	0.00	5.69	5.81	3.12	0.00
82	E14a_E14b	KnownJunction	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.42	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.03	0.00	0.00	0.00	0.00	0.00
83	E14a_E14c	KnownJunction	0	20.67	18.09	44.38	45.05	39.98	22.88	17.05	85.06	37.15	26.46	11.53	12.00	0.00	38.85	24.97	8.46	4.39	16.33	31.81	21.22	5.87	12.00	8.37
84	ER14b	ExonRegion	0	14.03	12.30	20.86	17.18	14.17	25.09	11.34	22.51	21.00	16.93	3.73	1.98	3.13	6.14	6.71	6.99	8.12	19.47	14.52	14.81	6.79	6.38	4.91
85	E14_Ab	KnownBoundary	0	38.53	11.77	32.46	25.11	15.37	49.80	22.74	19.35	29.28	19.72	4.26	6.30	8.12	4.65	8.90	8.37	3.46	39.01	17.69	9.01	3.09	5.27	0.00
86	ER14c	ExonRegion	0	26.98	15.56	26.23	15.78	16.55	27.83	14.30	28.11	24.41	19.37	5.04	2.89	4.20	5.63	12.83	7.93	6.78	20.81	22.88	12.78	6.13	7.48	4.51
87	E14_Db	KnownBoundary	0	13.78	26.97	26.79	14.98	23.09	49.74	20.80	41.07	27.46	28.47	2.42	12.60	0.00	14.30	13.85	3.85	13.84	27.48	21.74	5.37	3.15	5.45	7.51
88	ER14d	ExonRegion	0	20.14	11.90	26.66	19.05	13.60	29.25	7.59	19.21	19.54	23.78	4.68	2.32	2.73	6.07	9.15	8.25	8.35	26.85	10.97	17.25	6.11	4.49	4.36
89	E14_Ac	KnownBoundary	0	6.96	10.98	28.30	32.90	36.67	15.28	9.36	18.48	17.94	30.19	4.90	6.15	0.00	7.77	23.24	7.95	12.81	27.36	4.80	26.53	2.66	9.06	4.01
90	ER14e	ExonRegion	0	32.61	16.63	45.92	33.55	34.96	38.72	12.52	51.26	43.73	42.07	11.88	8.89	7.11	22.41	24.57	15.83	16.23	20.53	27.72	32.08	13.55	11.65	4.87
91	ER14f	ExonRegion	0	1.06	0.00	0.61	0.00	2.68	1.83	0.00	0.00	0.62	1.15	0.00	0.00	0.00	0.00	1.45	0.00	3.30	0.00	0.00	0.00	0.00	0.00	0.00
92	IG38_SR2	SilentIntergenicRegion	0	2.50	18.50	4.90	5.82	1.81	0.00	2.98	7.84	6.26	4.38	0.00	0.00	2.27	0.00	1.72	1.12	0.00	1.95	4.35	5.10	1.47	1.08	0.00