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W~ B!G B~  /usr/include/usr/include/bits/usr/lib/gcc/x86_64-redhat-linux/4.1.2/includeRNAduplex_cmdl.cstdlib.hRNAduplex_cmdl.hstdio.hlibio.htypes.hstddef.h %Xruvwpyswtutxoxtuvwvsv twtsvu{ tptuuu tvsJxt{ tuvqttitvtujtuuutntuwvswvuouyuuuxtv{vw|uKKKFAGNKKKuuuuuVLWK:Lf Js=:L>8}Y"o]E3y<,VVrrVV)R- =Yv >="Ʉ:>5/oW? (vt <v< +LY=c<fkK^w<4&:yI' Yvyy&Y z9X@:>4;/[xJ~+KZuIS"YWrf"YWrf"YWf<p<Xk<vn.Xqy~\~t~tXsh~t_fJ~f^f"z.]~/?{J}}th}<}feglQsue`ztltYs>tgt~Jt~fgutynY{te f!.$|D%|J-~X%fv!"{ ^$<tؑ^)=;u zfz..{N{3~GHY,t?{R|Dss#!/u~>.#>:IvegfֻL<|GXS#&J C{S.)RGYxtYxJ=]bYZ_a\":>Z_) %s="%s" %s RNAduplexhelpdetailed-helpfull-helpversionsortednoconvdeltaEnergytempnoTetradanglesnoLPnoGUnoClosingGUparamFilenspw2.0.0%s %s %s %s --%s: option `%s' is ambiguous hVse:T:4d:P:%s: invalid option -- %c 2%s: option unknown: %c%s Usage: RNAduplex [OPTIONS]... General Options: Algorithms: Model Details:%s: cannot dump options to stream %s: `--%s' (`-%c') option given more than once%s %s: `--%s' option given more than once%s %s: invalid numeric value: %s %s: cannot open file for writing: %s %s: option `--%s' doesn't allow an argument %s: option `%c%s' doesn't allow an argument %s: option `%s' requires an argument %s: unrecognized option `--%s' %s: option requires an argument -- %c Compute the structure upon hybridization of two RNA strandsreads two RNA sequences from stdin or and computes optimal and suboptimal secondary structures for their hybridization. The calculation is simplified by allowing only inter-molecular base pairs, for the general case use RNAcofold. The computed optimal and suboptimal structure are written to stdout, one structure per line. Each line consist of: The structure in dot bracket format with a "&" separating the two strands. The range of the structure in the two sequences in the format "from,to : from,to"; the energy of duplex structure in kcal/mol. The format is especially useful for computing the hybrid structure between a small probe sequence and a long target sequence. -h, --help Print help and exit --detailed-help Print help, including all details and hidden options, and exit --full-help Print help, including hidden options, and exit -V, --version Print version and exit Below are command line options which alter the general behavior of this program -s, --sorted print output sorted by free energy (default=off) --noconv Do not automatically substitude nucleotide "T" with "U" (default=off) Select additional algorithms which should be included in the calculations. -e, --deltaEnergy=range Compute suboptimal structures with energy in a certain range of the optimum (kcal/mol). Default is calculation of mfe structure only. -T, --temp=DOUBLE Rescale energy parameters to a temperature of temp C. Default is 37C. -4, --noTetra Do not include special tabulated stabilizing energies for tri-, tetra- and hexaloop hairpins. Mostly for testing. (default=off) -d, --dangles=INT How to treat "dangling end" energies for bases adjacent to helices in free ends and multi-loops (default=`2') With -d1 only unpaired bases can participate in at most one dangling end, this is unsupported for the partition function folding. With -d2 this check is ignored, dangling energies will be added for the bases adjacent to a helix on both sides in any case; this is the default for partition function folding (-p). The option -d0 ignores dangling ends altogether (mostly for debugging). With -d3 mfe folding will allow coaxial stacking of adjacent helices in multi-loops. At the moment the implementation will not allow coaxial stacking of the two interior pairs in a loop of degree 3 and works only for mfe folding. Note that by default (as well as with -d1 and -d3) pf and mfe folding treat dangling ends differently. Use -d2 in addition to -p to ensure that both algorithms use the same energy model. --noLP Produce structures without lonely pairs (helices of length 1). (default=off) For partition function folding this only disallows pairs that can only occur isolated. Other pairs may still occasionally occur as helices of length 1. --noGU Do not allow GU pairs (default=off) --noClosingGU Do not allow GU pairs at the end of helices (default=off) -P, --paramFile=paramfile Read energy parameters from paramfile, instead of using the default parameter set. A sample parameter file should accompany your distribution. See the RNAlib documentation for details on the file format. --nsp=STRING Allow other pairs in addition to the usual AU,GC,and GU pairs. Its argument is a comma separated list of additionally allowed pairs. If the first character is a "-" then AB will imply that AB and BA are allowed pairs. e.g. RNAfold -nsp -GA will allow GA and AG pairs. Nonstandard pairs are given 0 stacking energy. See also: RNAcofold(l) RNAfold(l) Written by: Ivo L Hofacker Report bugs: If in doubt our program is right, nature is at fault. Comments should be sent to rna@tbi.univie.ac.at. x $*J[@)$ EHYM&$uADG A[AASN $J^P$wJL nD,A,A,A<"BBB B(A0A8JOAG0%AzRx $4*J[@\)t$ EHYM&uADG A[A4ALSN $dJ^PwJL nD,A,A ,A4$"BBB B(A0A8J\OAG0|%AwwUSLUL]U]F\\VPVLSSLQQQLYYLtYY 7U7FU 2T27Q7ATAFQ -Q-7R7:Q (R7FRPQwQUwU\w\w PsUs7V8VVWVUVUVPeTe6S8USWSTS-5P8NPTTPPwwUSwKwUFSFKUPRU`awa{wqvUww UVUVSS w w U V V' T' ^ ^ Q. @ QK s Q Q Q Q & Q8 E QE M QW f Q R. > RK } R R R  R . R8 E RE M RW _ R0 X0 \ \ Y. H YK Y Y Y  Y . Y8 E YE M YW Y= = ]  . ]. H PH ] P ] P ]  P  ] . P. ]=  = _  _= 8= | X| 8 X 8 ' X' . 8. H XH 8 X 8  X  8 . X. W 8W v Xv 8= = R TR  T  T ' Y'  T W W  T X d S S S. S W S w  w U V V  R T \  \ P S  S V  V0 4 w4 w w w w w  w , w0 2 w2 4 w4 6 w6 8 w 8 9 w(9 : w0: D w8D Rw0 U R|0 T R|0 O QO R|0 R SRS0 X R| q]M]]C]h]]v]]]]|]]R] SS}SCSS51SS$SISSRS VVvVCVV51VV$VIVVRV |R| +\\\\C\\51\\$\I\\R\ ^ |*^P^^|C^Z^51^L$^'^]I^Y^^R^>HUbV^V^^pvV^"V"5^1L^LWV$CVCv^'-V-]^IYV^^&rXRkXTpXCX X0XXXoXX51Xh{X+X?XX X]yXYaXawR|XX q|q;]]|]C]h]]]]]]Y]] |R|`awahwhw0`U`T`QSS`sR`vX`YPPUTQwwUTQSSRPP RNAduplex_cmdline_parser_initRNAduplex_cmdline_parser_params_initRNAduplex_cmdline_parser_required( RNAduplex_cmdline_parser_dump RNAduplex_cmdline_parser_free RNAduplex_cmdline_parser_params_createP RNAduplex_cmdline_parser_file_save RNAduplex_cmdline_parser_print_version RNAduplex_cmdline_parser_print_detailed_helpRNAduplex_cmdline_parser_print_full_helpCRNAduplex_cmdline_parser_print_helpRNAduplex_cmdline_parser2]RNAduplex_cmdline_parserRNAduplex_cmdline_parser_extRNAduplex_args_info_purposeRNAduplex_args_info_usage RNAduplex_args_info_help1RNAduplex_args_info_full_helpWRNAduplex_args_info_detailed_helpmRNAduplex_args_info_description,[i[i[n|`g6K+iO|gnK`+6ejj R I$15C}  I$15C}  I$15C}  I$15Cp  I$15Cp  ]IY']$v1]5]pIY']$v1]5|uy ]hCCEEpY]'v hCEYyqt]n'v {hsCUpGPDcustom_getopt_longdefault_valuelongindRNAduplex_args_info_shortbuflast_nonoptRNAduplex_args_info_full_helpsorted_helpcustom_opterr_IO_lock_tRNAduplex_cmdline_parser_file_save_IO_buf_endnoTetra_helpoptoptRNAduplex_cmdline_parser_releaseexactRNAduplex_cmdline_parser_params_create_IO_write_endunsigned intnoGU_helpprint_errorsnoLP_givenparamFile_orig_flagsfull_help_helpparamFile_helpRNAduplex_args_info_help_markersvaluesshort intlong_optionsnoGU_givenARG_NOcheck_short_opterrorfoundargs_infooptstringRNAduplex_cmdline_parser_print_full_helpnoconv_givenwrite_into_filenoClosingGU_givenparamFile_given_posstdoutRNAduplex_cmdline_parseropterrfloatRNAduplex_cmdline_parser_print_detailed_helpRNAduplex_cmdline_parser_requiredfieldnameendRNAduplex_cmdline_parser_params_initresultlong long unsigned intparamFile_argnsp_arghelp_given_offsetRNAduplex_cmdline_parser_initcustom_getopt_initializevalue_filenoRNAduplex_args_info_usageupdate_argRNAduplex_cmdl.cinit_args_infoinit_full_help_arrayshort_optsize_tinitialize_vtable_offsetcustom_optinddetailed_help_help_IO_read_baseinitializedargc_IO_save_endcustom_getopt_internaldangles_origdangles_helpRNAduplex_cmdline_parser_extclear_args__s1_lencharoutfile_modearg_typeARG_STRINGfilenamecustom_optarglongoptsorig_field_IO_write_base_IO_read_ptrmultiple_optionRNAduplex_cmdline_parser_dumpexchangensp_origdeltaEnergy_helpnsp_helpRNAduplex_cmdline_parser2getopt_internal_rtemp_given_IO_marker__nptrlong long int__s2_len_IO_save_baseARG_FLAGcheck_ambiguityoptindpfoundnsp_givenopt_index__baselong_optdetailed_help_givenmiddle_IO_backup_baseARG_INThelp_helpdangles_arg__pad1__pad2__pad3__pad4__pad5prev_givenRNAduplex_args_info_detailed_helpfirst_nonoptdeltaEnergy_orignoTetra_givennoconv_flag__result__s1RNAduplex_cmdline_parser_paramsoptionfree_string_fieldversion_givenargv__endptrstop_charoverrideunsigned charoptionslocal_args_infoGNU C 4.1.2 20080704 (Red Hat 4.1.2-48)_IO_read_endno_freeRNAduplex_cmdline_parser_internaloptargstdinlong inttemp_argARG_FLOATnoconv_helpcustom_getopt_dataindfoundpackage_nameRNAduplex_args_info_purposenoLP_flagtempfield_givendangles_givenflagdeltaEnergy_argnextcharstring_fieldpossible_valuesnamebottomcheck_requiredfailuretemp_origtemp_helpgengetopt_strdup_lockfull_help_givenlong unsigned int_old_offsetnoClosingGU_flagoption_index_IO_FILEprint_help_commonadditional_errornoLP_helpsorted_givendeltaEnergy_givenversion_helpRNAduplex_cmdline_parser_arg_typeRNAduplex_cmdline_parser_print_version_sbuf_IO_write_ptrstrtodcustom_optoptstrtol/projects/remc_bigdata/miR/ViennaRNA-2.0.0/ProgsRNAduplex_cmdline_parser_freeclear_givenambigstderrnoClosingGU_help__off_tinit_help_arraysigned charsorted_flagshort unsigned intshuffle_argvprog_nameRNAduplex_cmdline_parser_print_helpARG_DOUBLEnoTetra_flagdoubleparams_chainFILE_flags2has_argnoGU_flag_cur_column_next__off64_t_unused2_IO_buf_baseRNAduplex_args_info_descriptioncheck_long_optGCC: (GNU) 4.1.2 20080704 (Red Hat 4.1.2-48).symtab.strtab.shstrtab.rela.text.rela.data.bss.debug_abbrev.rela.debug_info.rela.debug_line.rodata.str1.1.rodata.str1.8.rela.rodata.rela.debug_frame.rela.eh_frame.debug_loc.rela.debug_pubnames.rela.debug_aranges.debug_ranges.debug_str.comment.note.GNU-stack @p+@ &P1@!X 6@!I$DX.Z=UP f2+CZu2DHX0h xXP[H((^"~p00? 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