ELF>hG@@ fDHl$؉L|$D|-H\$Ld$Ll$Lt$HHIcD$H<HH1H5H AE1A @IAA\$9|AB.D$D)Hf.w7AGD9IcAHRHD"DrAD5D)HZBAD9}I9AuIcH@HH@@H\$HHl$ Ld$(Ll$0Lt$8L|$@HHEDD$IcH4vHH5H HDD$GAWAVAUIH?ATAHQ?USHAH$H$E1E1D$PD$TD$\D$`D$d A9HcHJ+LA8-uA@4<<$LHuD$PD$dAD$9}ITH HDPu .pH$HcI|1H@HA9?L$`tCMtLM!E1HA>-Lti1,tWHHcH WHEHc҈ t+:Nt#HHc׈ NGHH HuH=D$XD$HD$(|$H=Ƅ$HHt\H$><>HH1HHH=HHt<*tu<>u북|$4fDH1[]A\A]A^A_ÿ1:H=D$XD$D$XD$IvAH D$PAxIx1D$PvLHu  LHu LHu LHED$TLƉD$THuAD$9PHcMtMLHD$\AD$9'HcI|1r)H:H?S14%LH D$`Ax*AD$9XHcI|1zAD$9H$HcI|AD$9 HcM||:u:CHxHHI1HLAĉD$4ADHD$ D$4~HHǍCLIt HH9t'HHˆD$\uTuUHH9uـ|$FD$`Ht$ LZD$@HT$ 1L|$D$@H=$`H$H$HH$H! tH$H€DHAHHEH_ss.f@ps@HًH! t€DHAHEH_ss.f@gD$T|$4D|$PE9H|$(t H|$(H=LH|$ D$`D$\D$dD$PD$T~Ht$ LZD$@RDŽ$rna.fDŽ$psƄ$DŽ$rna.fDŽ$g#D$@5Ht$ H$Lt$41H=HHD$(HcT$4H|$ HD=HD$hG*L$4XY^D$HD$@Y$fW^D$H^|$4D$HD$HDd$`E|$41H|$(tT$4Ht$(H|$hHcl$`Ht$hLZD$8|$u DEu%D$8D E|$4H$DD$`HEHL$HZH$-H$H$H$H! t€DHAHEH_dp.f@ps@|$4E1.H|$ HD$pH|$ IHH@HI)A_9}IcAH@IDP@= g?HH|$ H9wLIcHT$pH$H@ALLID@@L=H|$pH|$hL$dD$8\D$@D$8^D$H ffDHt$hLj|$4"fDfDvfDDŽ$dot.fDŽ$psƄ$HLlHt$h1D\$XE9D$8|$4H=+Dl$`EHt$ LZD$@{H Z$|$4X ^THt$ $HHT$`D$|Ht$ LZL$|Ht$ ZH Ht$ L$HH$H$H$H! tH_dp2.ps€DHAHDHH9HT$pH$LAHHHt$ LHdot2.psH$....,....1....,....2....,....3....,....4....,....5....,....6....,....7....,....8% : ; I$ > $ >   I : ;  : ;I8 &I : ; : ; I8 I !I/  : ; I8 .: ;' @ .: ;' I@: ;I4: ;I4: ;I.: ;' I : ;I4: ;I.? : ; ' I@: ; I4: ; I4: ; I 4: ; I4: ; I 4: ; I U ! U"1UX Y#1$41%41&4: ; I'4: ; I? < (4: ; I? < 8intiih. b##### #(#0#8#@#H#P#X#`!#h#b#p'b#t)p#x-F#.T#/#3#<{#E#F#G#H#I-#Kb#M#n ?y  # # b#  ~  ; ib#jb#p# awHHbHplJiKbjKbkKbKb @22spt4@pl5i6bk6b['b&b&(())**~*~+,c,i-b-bl-bsym-br-b..kT//pf0b0b0b1b2b3b4-n-n-YF-F-G-G-H-H-I-I-J-J-)N-N-U\-\--- hbKݏ!pl1pl2"# !$% $+$5!meapl  ;  3&  (   ( '''' b' b'b'b'b''(pr$ '% b'&''b'(b')b ./../H/usr/lib/gcc/x86_64-redhat-linux/4.1.2/include/usr/include/usr/include/bitsRNAfold.cPS_dot.hstddef.hstdio.hlibio.htypes.hfold_vars.h fTy7k .ttY>HKx<BXZY9wˑY;=;gI=wJ t~Ȕsi!7Z~<rjwVqgK&;s`&" J=u:L/~tHY:\i=Nu";YC!~-u~huJ;Yg%fsYle&!hd/KW==׃KL6J5XKX5XYW=>H=\*C<=CJ=uAtY ȟ ,١ ~~^-jz"u/(GzWZ&=YIgLXo& Ɂ=gKI t usage: RNAfold [-p[0|2]] [-C] [-T temp] [-4] [-d[2|3]] [-noGU] [-noCloseGU] [-noLP] [-e e_set] [-P paramfile] [-nsp pairs] [-S scale] [-noconv] [-noPS] [-circ] [-MEA [gamma]] warning, depending on the origin of the circular sequence, some structures may be missed when using -noLP Try rotating your sequence a few times Input constraints using the following notation:< : base i is paired with a base j : base i is paired with a base j>imatching brackets ( ): base i pairs base j Input string (upper or lower case); @ to quit minimum free energy = %6.2f kcal/mol free energy of ensemble = %6.2f kcal/mol Probabilities for stacked pairs (i,j)(i+1,j-1) frequency of mfe structure in ensemble %g; %lf%d-noGU-noCloseGU-noLP-noPS-nsp-noconv-circ-MEA| : paired with another base. : no constraint at allx : base must not pair%s%s >%12s%sconstraints missing length = %d %s %s (%6.2f) scaling factor %f [%6.2f] %s {%6.2f d=%.2f} %s {%6.2f MEA=%.2f} ensemble diversity %-6.2f@?fffffq@%zr?@@h㈵>-C6?x  ,_EG]P<BBB O(N0A8GzRx  $4_EG]P4\BBB O(N0A8G9w9ow<U<#V<oVOaOo@RTUeoUq(\(<S<o\||S|^<<S<o^tDX!7_<o_prwrtwtvwvw w(w0w8 wpUT\[\ \m w \*:\Z\pTV][ ] =]v].]X^[^x ^ m ^w *^:Z^ ^PQSxS}x } m }w *}:Z} }}x } m }w *}:Z} }Z_[ _ _:_Z_v_^eXeX^[:^:qXq~^~X+^+^X^^X^X6^6FXF[^[hXh^m r Xr w ^*5X5:^Z_X_u^uzXz^X^TTVPVUQ#P3ZQdsPs~Q~V2RV[VPxVm w V*:VZV~x ~ m ~w *~:Z~ ~XXPPPPP~P5P|PP+6P~x ~ m ~w *~:Z~ ~~x ~ m ~w *~:Z~ ~~x ~ m ~w *~:Z~ ~c c ::ZZ88..@@  ~ ~ ~ ~~~x ~ m ~w *~:Z~ ~ ~ ~ ~ ~ ~ ~ ~x ~ m ~w *~:Z~ ~~x ~ m ~w *~:Z~ ~]S[[S[]x ] S m ]w ] S:Z]]Sv]S@X]XS S SSx  m w *:Z  U UC J UZ_[_x _ _ m _w _ *__v_@ _V2RV[V V VVV@ VT\[\x\ \ \\\@ \~x ~ m ~w *~:Z~ ~aS[S S SSPUSS Fmain,    v:Z @  w g k Z w g k J Z C E  > _shortbuf_IO_lock_tstderrsfact_IO_buf_endcstrucgfname_IO_write_endunsigned int_flagsline_markersshort intmake_plistdangles_pospf_strucRNAfold.c_IO_write_baselong long unsigned intdoMEApf_scaleParamFile_offset_fileno__pad3cent_ensize_t_vtable_offsetnonstandards_IO_read_baseenergy_set_IO_save_endenergystring__resultargvnoPStemperature__s1_lencharpmin_modeno_closingGU_IO_read_ptrtetra_loopstrucscale2iindx/projects/remc_bigdata/miR/ViennaRNA-1.8.5/Progs_IO_markerb2plistlong long int__s2_lennoGU_IO_save_baseMEAgammaisttystdout_IO_backup_basens_basesdist__pad1__pad2__pad4__pad5maxlfname__s1centfold_constraineddo_backtrackunsigned charGNU C 4.1.2 20080704 (Red Hat 4.1.2-48)_IO_read_endmea_enlong intlengthnoLonelyPairsusageplist_locklong unsigned int_old_offsetstdin_IO_FILEfloatargcrcsidnoconv_sbuf_IO_write_ptrffname__off_tcircsigned charshort unsigned int$Id: RNAfold.c,v 1.25 2009/02/24 14:22:21 ivo Exp $scale1maindouble_chainmin_enstructure_flags2_cur_column_next_unused2_IO_buf_base__off64_tGCC: (GNU) 4.1.2 20080704 (Red Hat 4.1.2-48).symtab.strtab.shstrtab.rela.text.data.bss.debug_abbrev.rela.debug_info.rela.debug_line.rodata.str1.8.rodata.str1.1.rodata.cst8.rodata.cst16.rela.rodata.rela.debug_frame.rela.eh_frame.debug_loc.rela.debug_pubnames.rela.debug_aranges.debug_ranges.debug_str.comment.note.GNU-stack @ HZx&`i ,1D ?lUPpa2 p2#,%00%@%('@'ІHX(@??000? 0AV F.7F7F.hOX" W  _   @)#)* *0 6 < B H N (T Yagmpyp~ !(/:?LW_kr"*9AN_ltxRNAfold.cusagemake_plistscale2scale1.LC48.LC31.LC32.LC33.LC34.LC39.LC44.LC3nrerrorspaceiindxprxreallocmaindo_backtrack__ctype_b_locsscanfnoLonelyPairsread_parameter_filenonstandardsstdoutfilenoisattystdinget_lineputsfreefree_arraysprintffold_constrainedstderrfwritetetra_loopnoGUno_closingGUenergy_setdanglestemperaturestrlen__ctype_toupper_loccircfoldfflushstrcpyfoldPS_rna_plotstrncpyexppf_scaleinit_pf_circ_foldpf_circ_foldcentroidenergy_of_circ_structmake_pair_tablePS_dot_plot_listputcharfree_pf_arrayspf_foldinit_pf_foldenergy_of_structmean_bp_distfprintfMEAstackProb K#`$g%P&W$^%(. 8 7a) *+,#--6-S-g-./012 *34 12C5\ a3f @k p w61/07 X3 <3 Y3 r3 3 3 38, 19<:a (f m* ; < +  $1 )b =g v*> > *7 1 ?  %*{@# *4@#7A`By ~6 86.CD/ D 4 . 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