ELF>`@@ ATISHxLHHÃHcHcHD&Hc5Jt&HH[A\@AUIATUSHxHIL1&LHHD)LhHcH{&H9¸CHt ;tHAHʈHzu~.t99tH=1LHL[]A\A]É-fDfDAWE1AVAUATUSHH<$(ID$ HD$7Od>O,>H1ILLHHD$~NH<$Dd$HHt(\$ AD$9LIƉ\$ IcHM,Md1I$IEH[]A\A]LA^A_f.Hl$Ll$Lt$L|$IH\$Ld$HILD$MXY^D$t *}LHHZ*YfW^D$^HLHLLH|$H5HLH\$XHl$`Ld$hLl$pLt$xL$HĈD-ÉD$LIHLLE߉LHH*L$ZYfW^D$^HLH|$ HLHD$ T$H5H|$IHD$(IGHD$0IGHD$8IGHD$@IG LHfAWAVAUATUSHL$HDŽ$HDŽ$HDŽ$HDŽ$LhD$E"$$$$w$M$/$D$$$1D$$4$1ۅ$ D$`D$D$lD$tEuD$lD$tD$D$xEtD$lD$tD$xD$HD$HD$|E>D$Et$`D$ltLHtHH!E1H;-Hti1,tWHHcH WHEHc҈ t+:Nt#HHc׈ NGHH HuH=DŽ$D$pD Eu $$H$H$H$H$H DD$pE H$1H$xHH$x5IƅH$H$H$HDŽ$҃>H$9H$t H$E1H/ HA 9u~AT$HLHcL$ H$T$pt%` p)1D$xt?D$| H|$HHHH)HH$H$LZH$LD$P=_ H$mLIbH1HLD$p D$PH=D$H$1$$ H$H$0H$0H! t€DHAHEH_ss.f@ps@L$xHPDEL1H$0E1LHLLH D$l= *XY^D$XD$`YD$PfW^D$X^D$HD$H* H$HtULHcH$H$0L$8$ $$\D$P$^D$X$@D$$HD$ $PD$(D$\D$ \D$(H5H$Dd$tE =t 뉄$+$$$C$Ilj\$4Hc$H$LHHH$Hc$HH$H$L$L$L$H$L$L$H$H$L$L$L$L$L$H$H}H$H$H$$T$(L$ $0H$$H$$f($H$H$H$H$$f($݄$d$(\$8\$ ݄$T$8\$@D$L$@D\$xEM$H$H$0H$0H! tI_dp5.ps€DHAHDHLL$D$L$`L$H$0LfDŽ$`ABƄ$bH$H$MH$LD$@LH$0LfDŽ$`AAƄ$b$|LHHHLH$H$MLHHD$8LH$0LfDŽ$`BBƄ$b$|HHHHHH$H$MD$4LH߉HD$ LH$0LfDŽ$`AH$H$MLLD$(LH$0LfDŽ$`BH$H$MLHLHH$H$H$H$H$H$H$H$H$H$fDDE$,H$H$0H$0H! t€DHAHEH_dp.f@ps@|$tut$l9H$H=H$HtH$HtH$LH$Ht/H8HtH$H<HHuHT$pHDŽ$HDŽ$HDŽ$HDŽ$$D$`5$֋$ʋ$$҉RNj$(Nj$ʋ$H$Hŋ$h D$PHH$5L$tfDH$HfDH$LIHDŽ$0rna.fDŽ$4psƄ$6VH=#H$DŽ$0dot.fDŽ$4psƄ$6H$?Ƅ$FH=LxHË0PLHHcHf&Hc5HJt6H޿1D|$pEuu$D-Ey(1Idot5.psL$0H1[]A\A]A^A_ÿ H$1LZD$P*H$H$H$0H$AH$H$L$@d$(E1\$ T$8D$H$H$fWAHf.w@f.wE~eH$E1Kf(As0Xk(c [SH8^^^^^E9uH$H$}H=DEDŽ$D$pH$D$lHD$HD$tD$xD$|H$PHH$8HL1H$H$>HT$HH=1HsAV@ fD% : ; I$ > $ >   I : ;  : ;I8 &I : ; : ; I8 I !I/  : ; I8  : ; .: ;' I@: ;I4: ;I4: ;I4: ;I: ;I U4: ;I4: ;I .: ;' : ;I: ;I .? : ; ' I@: ; I4: ; I 4: ; I!4: ; I"4: ; I#4: ; I$ U%4: ;I &1X Y'1(41)!I/*4: ; I+4: ; I? < ,4: ; I? < .8intii.s. b##### #(#0#8#@#H#P#X#`!#h#b#p'b#t)p#x-F#.T#/#3#<{#E#F#G#H#I-#Kb#M#y  # # b#  ~  4 'i(b#j)b#p*4#+( #FAB# #FA#FB# F 8A0#B0#ABc#AAc#BBc# Ac#(Bc#0 ' (s# )s# *s# +s# ,b# -s#( .b#0 /s#8 0b#@ 1s#H 2b#P 3#X 4s#` 5b#h 6s#p 7b#x 8s# 9# :# ;s# <# =# >s# ?# @# As# Bb# Cs# Db# E# Fs# Gb# Hs# Ib# Js# Kb# Ls# M# N# Os# P# Q# Rs# Sb# T# Us# WM# XM# YM# ZM# [M# \M# ]M# ^M# _M# `M# aM# bM# cM# dM# eM# fM# gM# hM# iM# jM# kM#\   len bposcutbG cfpcG efigbngbclb bbtpr  kT X!  PPPPFEAPFEBPPR iSbnSbtot[ "b!b!#w $M % %!&&&!&&' |' |!(!)"c)!*"i+b!+b#l+b"sym+b#r+b"cl+b!,"kT-!-"pf.b!.b /b /b"doT0b"doC1b#doQ2b!3b!4!5!6"prA7"prB8!9!:!;"mfA<"mfB=!>?MP!?M$ "cpb M$ "fpG $ %"s$AB.~AA.}BB.}XbXbYYZ%[3~%\ {$@& 'd 'X 'L '@ '4 '( $(p (| ( (  O; 3) C  S 4*C++++b+b+b+6b+;b+@b+Gb+Pb+g+o,pr++b /usr/include/usr/include/bits/usr/lib/gcc/x86_64-redhat-linux/4.1.2/include./../HRNAcofold.cstdio.hlibio.htypes.hstddef.hdata_structures.hRNAcofold_cmdl.hfold_vars.h Y>v:ZYɁ=;=g=;==u. gh1 X;=j;_=g;=!N"KL!΃I.eujvd"u2Ng-us?qu?9vY-=-=,,,,95:CKIx~wiY#w!Z;=Ʌw!Z;=-KegY-[ZwZQGKLZ!!Ʉ'F$ן}t<Vrrv,hrrr,v Q ~fX`;=a"}"# /="J}.f~<gǟ+ ?9hVYuKWYWILWK:L]~c ~ICtw7HJ< u%scut_point = %d cut = %d %lf %lf>%42slength = %d length1 = %d length2 = %d r %s %s (%6.2f) scaling factor %f [%6.2f] , delta G binding=%6.2f A B AB AA BB A Bdoofmore than one cut-point in inputSequence and Structure have different cut points.Error in get_partfunc , computing neither mono- nor dimere!Use '&' to connect 2 sequences that shall form a complex.Input sequence (upper or lower case) followed by structure constraint cut point in sequence and structure constraint differsstructure constraint is missingstructure constraint is shorter than sequencestructure constraint is too longcould not open concentration file %sPlease enter concentrations [mol/l] format: ConcA ConcB return to end minimum free energy = %6.2f kcal/mol 1 %d 9 0 0.9 0.2 omark %d %d 9 1 0.1 0.2 omark free energy of ensemble = %6.2f kcal/mol frequency of mfe structure in ensemble %gSorry, i cannot do that with only one molecule, please give me two or leave itFree Energies: AB AA BB A B %.6f %6f %6f %6f %6f Initial concentrations relative Equilibrium concentrations%-10g %-10g %.5f %.5f %.5f %.5f %.5f %%Heterodimer AB FreeEnergy= %.9f %%Homodimer AA FreeEnergy= %.9f %%Homodimer BB FreeEnergy= %.9f %%Monomer A FreeEnergy= %.9f %%Monomer B FreeEnergy= %.9f fffffq@%zr?@@Q?h㈵>Q?fffffq@%zr?@@h㈵>33s?33s?x $\BDD ,BEA A(D0<BEB B(A0A8DP,WJLT<BBB B(A0A8GzRx \BDD $<BEA A(D04dBEB B(A0A8DP$WJLT4BBB B(A0A8Gww w \w U[\#1U;QU`bwbgwghwhiw imw(mTw0`rUrK]LT]PFSLTSPQI\LT\GVLTV`bwbgwgiwikw klw(lmw0mqw8q6w`zUz6*V3^ PS SS@jwjw@Ty^^@QjVV@RRR@X~@Yt]]UUU/4TUT "T*5QX]UTT,4QUwwww w(w0w8wUTr^r^5^[^UllqUq~~UVVlVtV5V[uV2S) SG SSSS'JSlSJ]St~S5S[uS9T[gTGrrrurUQP Q"P"4Qr VVr]VtV V5V[V9X[bX}\P \\\\'J\J]\ P %\%/P/5\4[\rrr5r[rrrr5r[rrrrrurrrrur[rr5rr[rrrrurrrrurOrrrurrr5[rr5[rr5[rr5[r~r5~[~r~r5~[~r~r5~[~r~r5~[~r~r5~[~r~r5~[~rrr5r[rSrr5rr[r2zS& ) P) SS4[Sr}\o \\r\]\t\ \ \4[\r2S) SG ~ SSSrSS@]St~S Srrr5r[rrrr5r[rr_r_@_5_[_rV VVJV@JV]VVUU#U&+U~UUUUUUU Trrr5r[r0]]t]]H\]t\ \h2 main, 5 G 4['Jy 'r ' 4 ]t@x  4 ]t+  D7<size_tNewstring_IO_save_endread_concentrationsstartcnoLP_given_IO_write_basenoClosingGU_helppartfunc_givenfull_help_given_lock$Id: RNAcofold.c,v 1.7 2006/05/10 15:14:27 ivo Exp $argvBstringparamFile_argistty_IO_save_basetempstrucprAAversion_help_chaindetailed_help_help_cur_column_modefold_constrainedconcfile_helpdo_concentrationsstderrsfactnonstandardsRNAcofold.cdetailed_help_givenFILElong intnoTetra_flagpfScale_givenpfScale_orig_IO_markermainshort unsigned intcopypstringdangles_helpfull_help_helpAstringhelp_helpsigned char_IO_FILEunsigned charplistcommentargs_info_sbufinput_stringRNAcofold_args_infoF0ABparamFile_helpchar_IO_lock_tctmpconstraint_flagnoconvmfBBdangles_argdangles_origdangles_given_IO_read_ptrdouble_posstdinall_pf_givennsp_argAlength_markersConcfilepartfunc_argconstraint_givenmfplFEAArec_typetemp_givennoGUGNU C 4.1.2 20080704 (Red Hat 4.1.2-48)Blengthinput_typecoptionslong unsigned intpstructns_bases/projects/remc_bigdata/TCGA/RNA/ViennaRNA-2.0.0/Progs_flags2energyModel_arg_IO_read_baseparamFile_given_unused2cstrucdanglesnoClosingGU_givenpartfunc_helpresult_old_offsetConcAandBenergyModel_helpno_closingGUdo_backtrackrec_restFEABtokenizercsidlong long intrec_id_IO_write_endenergyModel_origFcABdo_partfuncprAB_IO_buf_basestring_nextunsigned intParamFile__pad1__pad2__pad3__pad4__pad5noconv_given_flagsmfAAConcEntconcfile_orignoGU_flagprBBconstraint_helpnoconv_helpargcnsp_givencofoldF_offsetnoconv_flagnoClosingGU_flaglong long unsigned intpf_scalepfScale_helplengthNewname__off_tstructurepartfunc_orignoPS_helpversion_givenread_optconcentrations_flag_IO_backup_base_shortbuftemperaturenoPS_flagffname__off64_tnoPSSwitchenergy_settemp_arg_IO_buf_endcofistartconcnoGU_givenconcentrations_helpshort intnoGU_helptetra_loopnoLP_helphelp_given_vtable_offsetmfABrec_sequencefnamenoLP_flagpfScale_argFEBBnoTetra_helpmin_en_IO_read_endnsp_origcostringtemp_help_filenonsp_helpconcentrations_givenfloatstdoutnoPS_givenenergyModel_given_IO_write_ptrnoLonelyPairsall_pf_helpcostruccut_pointtemp_origlineannotconcfile_argparamFile_origconcfile_givenall_pf_flagnoTetra_givenGCC: (GNU) 4.1.2 20080704 (Red Hat 4.1.2-48).symtab.strtab.shstrtab.rela.text.data.bss.debug_abbrev.rela.debug_info.rela.debug_line.rodata.str1.1.rodata.str1.8.rodata.cst8.rodata.cst16.rodata.cst4.rodata.rela.debug_frame.rela.eh_frame.debug_loc.rela.debug_pubnames.rela.debug_aranges.debug_ranges.debug_str.comment.note.GNU-stack @v&,1ID2?@UC,Pa2>0p215P6 068688 ذX9ȱxP:@S@S0X0S0V_.&__6h ) s| \  ``  3@W? D I N S Y_ e (kq 0w 8} @  H .:EH]ov )7CJPW^elt  *39MUiRNAcofold.ccostringtokenizeread_concentrationsdo_partfunc.LC6.LC7.LC8.LC9.LC10.LC11.LC12.LC14.LC28.LC34.LC35.LC36.LC37.LC43strlenspacecut_pointstrncpystrcatsscanfstrchrnrerrorstderrfprintffreeget_linexrealloctemperatureputsexitfoldexppf_scaleassign_plist_from_dbfree_arraysco_pf_foldprassign_plist_from_prfree_co_pf_arrayscofoldfree_co_arraysmaindanglesdo_backtrackRNAcofold_cmdline_parserRNAcofold_cmdline_parser_freeread_parameter_filenonstandardsstdoutfilenoisattyfold_constrainedread_recordgetConstraintstr_RNA2RNAprintffopenfclosefflushmemsetstrcpysprintfPS_rna_plot_astrncatcompute_probabilitiesPS_dot_plot_listprint_tty_constraintprint_tty_input_seq_strno_closingGUnoGUnoLonelyPairstetra_loopenergy_setstr_DNA2RNAwarn_user__strdupstdinprint_tty_input_seqputcharenergy_of_structureget_concentrations )*+-,4+C+M-n)v*{ ./)/ 0 +1! (2- (20:3N+{* .345n6 `78+*9:;<#=1>=?G L@QAY3*--+*B:;< C0>@?M y@~A33EFG!{FHI*JJJJJ0K5L<M^NO $.+)*N.+GPZ+i (n0),Q+ 7R R SC TS Bp "u <{ + V R H R K U  V- W + p X Y 3 3 E # 6 $ %0 &? :W ;x , > F  R :  R H RO ?a 'f @z + E + * * Z Z [-[g[s XRW7 LXv+{-\ (X-*W-\'32 P?Xa-q*W-+\3 x+X-\ ,XF-d\l3t33333333333F/W3AKU33333"3c h7nN] ^_`aEb.NT6icy \Rd `eCff( -74gm71 f2)*+,)+- R y'R.FAhM *TRiEjE \33k8 E7J O7 R33 E e& +08g=LDMQ V7]Np]u z^fff R  73+3<1A H2M TR0hh8   % ) . 9 @ IG N eU 4\ aj q q|     @    F D d  K, '; J Y h >w    .  #     | # 3 C S /c d   _ o  5   W5 :< WK S o 5  $ - *; I W e s      P       M + : FI X g Uv              k* $9 SH W f u .   6 $    s   ] ) G8 dG !V %e t     9 B | T  R #\+ 0 X; `@ K a m`uT}   T    B `6 x )  a 2  . 3 A R :^ @f n 8s X~ q b     L n     <  m T) 5 sA e 8q          e  X u y# ( m7 F P 7U d s  r   V J G   b Q      #  r $ m.  < %A K tP [ p  ' 3 v F     c    P     =/ 4 > C xP Z *c @q v            0    % 60 5 "@ 4E P U ` 8e iu ]     0 <   p T ^ c p @} f  5 r t   u  s  L%   D H`t x` @  @ `h ` @