#ifndef __VIENNA_RNA_PACKAGE_MEA_H__ #define __VIENNA_RNA_PACKAGE_MEA_H__ #include "data_structures.h" /** * \file MEA.h * \brief Computes a MEA (maximum expected accuracy) structure. */ /** * \brief Computes a MEA (maximum expected accuracy) structure. * * The algorithm maximizes the expected accuracy * \f[ A(S) = \sum_{(i,j) \in S} 2 \gamma p_{ij} + \sum_{i \notin S} p^u_i \f] * Higher values of \f$\gamma\f$ result in more base pairs of lower * probability and thus higher sensitivity. Low values of \f$\gamma\f$ result in structures * containing only highly likely pairs (high specificity). * The code of the MEA function also demonstrates the use of sparse dynamic * programming scheme to reduce the time and memory complexity of folding. */ float MEA(plist *p, char *structure, double gamma); #endif